卵巢上皮性癌患者血清和腹水中血管上皮因子测定的临床价值  

Clinical application of endothelial growth factor to diagnosis and monitoring of epithelial ovarian cancer

作　　者：周家德[1] 孙昕[2] 颜士杰[1] 沙玉成[1] 

机构地区：[1]安徽医科大学第一附属医院妇产科,安徽合肥230022 [2]安徽医科大学第一附属医院中心实验室,安徽合肥230022

出　　处：《安徽医药》2007年第4期329-330,共2页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省教育厅科研基金资助项目(2002KJ170);安徽省卫生厅科研立项项目(2002B058)

摘　　要：目的 测定卵巢上皮性癌患者血清和腹水中血管上皮生长因子（VEGF）的含量，探讨VEGF在卵巢上皮性癌的诊断、病情监测、预测复发中的价值。方法 采用酶联免疫吸附试验测定卵巢上皮性良性肿瘤（良性组）30例、交界性肿瘤（交界性组）7例、恶性肿瘤（恶性组）33例患者血清和腹水（或腹腔冲洗液）中VEGF的含量。结果 恶性组术前血清和腹水中VEGF的量明显高于交界性组和良性组（P〈0．05）；交界性组、恶性组术后血清VEGF的量较术前明显下降（P〈0．05）；恶性组Ⅲ一Ⅳ期术前血清VEGF的含量明显高于Ⅰ-Ⅱ期（P〈0．05），病理分级G2-G3的明显高于G1（P〈0．01）；10例复发患者血清VEGF的含量明显高于23例未复发者（P〈0．05）。结论 血清VEGF水平与卵巢上皮性癌的生长、预后有关，具有肿瘤标记物特性。可作为卵巢上皮性癌的诊断和病情监测指标。Aim To determine the vascular endothelial growth factor （VEGF） levels in serum and ascits of the patients with epithelial ovarian cancer, and to evaluate the clinical application of VEGF in diagnosis and monitoring of epithelial ovarian cancer. Methods Serum and ascits VEGF concentrations in 30 patients with benign ovarian carcinoma （benign group） ,7 patients with borderline ovarian tumor （borderline group）, and 33 patients with epithelial ovarian cancer （malignant group） were measured by sandwich enzyme-linked immunoadsorbent assay （ELISA）. Results Serum and ascits levels of VEGF were significantly higher in malignant group than those in benign group and borderline group（ P 〈 0.05 ）. Serum VEGF levels decreased signicantly （ P 〈 0.05 ） in malignant group and borderline group optimal removal of tumor bulks. In malignant group, statistical analysis showed that serum VEGF levels in clinically advanced patients （ stage Ⅲ and Ⅳ ） were significantly higher than those in early stage （ stage Ⅰ and Ⅱ ） patients （P 〈 0.05 ） ,and were significantly higher in histopathologic grades G2 - G3 than those in G1 （P 〈 0.01 ）, on the other hand, the serum-VEGF levels of 10 patients with recurrent were significantly higher than those of 23 patients without recurrence（P 〈0. 05 ）. Conclusion Serum VEGF with the characteristics of tumor markers shows a stronge relationship with growths, metastases, outcomes of epithelial ovarian cancer. So it can be one of the parameters of diagnosis and illness monitoring in epithelial ovarian cancer.

关 键 词：卵巢上皮癌 血管上皮生长因子 血管生成 肿瘤标记物 

分 类 号：R737.31[医药卫生—肿瘤]