液闪探测PMN Ly化学发光及其细胞外间质成分改变与肝纤维化关系研究  

Study of Liquid Scintillator in Detecting the PMN CL, Ly CL and Extracellular Matrix in Liver Fibrosis

作　　者：李天星[1] 曹锐[1] 梁启中[1] 邹晓薇 

机构地区：[1]第三军医大学大坪医院

出　　处：《核电子学与探测技术》1997年第2期150-153,共4页Nuclear Electronics & Detection Technology

摘　　要：肝硬化患者血中多形核白细胞、淋巴细胞化学发光的活性氧自由基和细胞外间质变化与早期肝纤维化形成关系密切。结果表明，化学发光是氧自由基生成释放的过程，肝纤维化细胞外间质受氧自由基作用生成过脂质氧化物损伤细胞膜和组织，而透明质酸和胶原等受降解致使细胞外间质沉聚，这可能是成为肝纤维化早期阶段。所以，化学发光分析有助于细胞动能和细胞外间质的关系及肝纤维化形成机制的研究。Chemiluminescence(CL) of polymorphonuclear(PMN) and lymphocyte(Ly) in blood of patients with cirrhosis has two peaks. Basic peak value of PMN CL and Ly CL is increased, the maximal peak values of Zym PMN and PHA Ly are decreased, phagolyosis and opsonic function is also decreased, extracellular matrix(ECM) is all increased, HA is positively correlated with "child" sort ( r =0 96,A>B>C). It suggests that OR is produced and released during CL and superoxide phosphatide is produced by OR in ECM of cirrhosis. It injures the membrane of cells and tissue. Analysis of CL is aided to study the development mechanism of liver fibrosis. (

关 键 词：化学发光 氧自由基 肝纤维化 液闪 肝硬化 

分 类 号：R575.2[医药卫生—消化系统]