氯普噻吨注射液与氟哌啶醇注射液治疗急性期精神分裂症的对照研究  

A controlled study of chlorprothixene injection and haloperidol injection in the treatment of acute schizophrenia

作　　者：江琴普[1] 栗克清[1] 胡景荣[1] 孙东[1] 李建峰[1] 杨老虎[1] 李薇[1] 张香云[1] 

机构地区：[1]河北省精神卫生中心,071000

出　　处：《上海精神医学》2007年第2期98-100,共3页Shanghai Archives of Psychiatry

摘　　要：目的比较氯普噻吨注射液与氟哌啶醇注射液治疗急性期精神分裂症的疗效和副作用。方法71例患者随机分为氯普噻吨组(n=33)及氟哌啶醇组(n=38)进行治疗,分别在治疗前及治疗后采用阳性与阴性症状量表(PANSS),临床总体印象量表(CGI)及不良反应量表(TESS)评定其疗效及药物不良反应。结果氯普噻吨注射液对控制急性精神分裂症的兴奋、躁动疗效与氟哌啶醇注射液相当,统计学无显著意义(P>0.05),但锥体外系不良反应较氟哌啶醇注射液少。结论氯普噻吨注射液与氟哌啶醇注射液治疗急性精神分裂症的疗效相当而不良反应较少。Objective： To compare efficacy and adverse effects of chlorprothixene and haloperidol in the treatment of acute schizophrenia. Methods： 71 patients were divided randomly into chlorprothixene group （33 cases） and haloperidol group （38 cases）. Positive and Negative Syndrome Scale （PANSS） , Clinical Global Impressions （CGI） and Treatment Emergent Symptom Scale （TESS） were used to evaluate efficacy and adverse effects of medications before and after 7 days of treatment. Results：The difference was not statistically significant between the two different therapeutic schemes （ P 〉 0.05）. The rate of some adverse effects （EPS） in chlorprethixene group was decreased more significantly than that in haloperidol group. Conclusion： Chlorprethixene and haloperidol have similar effect on the treatment of acute schizophrenia. With fewer adverse effects, chlorprethixene is superior to haloperidol. Chlorprothixene is an effective new drug in schizophrenia treatment.

关 键 词：氯普噻吨注射液 氟哌啶醇注射液 急性精神分裂症 疗效 不良反应 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]