增殖诱导配体及其在肿瘤发生发展中的作用  

A proliferation-inducing Iigand and its role in genesis and development of tumors

作　　者：唐菁（综述）[1] 张玲（审校）[1] 

机构地区：[1]山东省医学科学院基础医学研究所山东省医药卫生肿瘤免疫与中药免疫重点实验室山东现代医用药物与技术重点实验室,济南250062

出　　处：《国际肿瘤学杂志》2007年第4期241-244,共4页Journal of International Oncology

摘　　要：增殖诱导配体（APRIL）是近年来发现的肿瘤坏死因子（TNF）超家族成员。通过对APRIL的基因蛋白结构、组织表达、信号传导通路的研究，发现它在多种肿瘤细胞内表达，并对肿瘤细胞的增殖和抗凋亡发挥重要作用。抑制APRIL与其受体结合、阻断其信号传导通路可明显抑制肿瘤细胞的增殖从而为肿瘤的治疗提供新途径。A proliferation-induced ligand （APRIL） is a recently found member of tumor necrosis factor （TNF） superfamily. Studies on the gene and protein structures, tissue expression of APRIL and signaling pathway indicate that APRIL expresses in many tumors cells, and has very important role on cell proliferation and anti-apoptosis. Preventing APRIL from binding to their receptors and blocking their downstream signaling pathways can obviously inhibit tumor cells proliferation, which probably provide new methods for tumors treatment.

关 键 词：肿瘤坏死因子类 肿瘤 细胞增殖 细胞凋亡 

分 类 号：R730.2[医药卫生—肿瘤]