胃肠道恶性肿瘤腹膜转移热灌注化疗研究进展  

lntraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis from gastrointestinal carcinoma

作　　者：董力枫（综述）[1] 王林波（审校）[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院肿瘤外科,杭州310016

出　　处：《国际肿瘤学杂志》2007年第4期282-285,共4页Journal of International Oncology

摘　　要：腹腔内热灌注化疗（IPHC）可提高大肠癌、胃癌等胃肠道恶性肿瘤腹膜转移患者的生存率，但对不同分期、不同部位来源腹膜转移患者的效果有所区别，且有部分患者对IPHC耐受性较差。因此需要严格掌握适应证和禁忌证。IPHC常用的药物有奥沙利铂、顺铂、丝裂霉素C等，具体方法不同机构常有所差别，尚有待标准化。Intraperitoneal hyperthermic chemotherapy （IPHC） has improved the survival rate of patients with peritoneal carcinomatosis from gastrointestinal carcinoma. However, the effects of IPHC vary according to stages and origins of the peritoneal carcinomatosis, and some patients have poor endurance to IPHC. So great care should be taken in selecting patients to undergo this procedure. The IPHC is often proceeded by a closed continuous circuit ,which is composed of isotonic perfusate with drugs like oxaliplatin, cisplatin, mitomycin-C,et al. But the technique varies from different teams, further works are needed to make the procedure standardized and available to more patients.

关 键 词：腹膜肿瘤 热 输注 胃肠外 药物疗法 

分 类 号：R735.5[医药卫生—肿瘤]