手术加放疗治疗下咽癌32例临床研究  

Clinical research of 32 cases of hypopharynx cancer treated by operation and adjuvant radiotherapy

作　　者：付卫江[1] 杨秋安[1] 韩雯斐[1] 潘振华[1] 付雷[1] 宫良平[1] 

机构地区：[1]山东大学齐鲁医院肿瘤中心,济南250012

出　　处：《国际肿瘤学杂志》2007年第4期312-313,317,共3页Journal of International Oncology

摘　　要：目的评价手术加放疗治疗下咽癌的疗效和毒副反应。方法1998年4月至2000年3月在齐鲁医院接受手术加放射治疗的下咽癌患者32例，分期T2-4N0-2M0，手术采用咽喉肿瘤切除术及颈部淋巴结清扫术，术后2～4周伤口完全愈合后进行放射治疗，剂量为55～66Gy，观察治疗毒副反应，放疗结束后定期随访，采用Kaplan—Meier法进行生存率评估。结果所有患者均顺利完成治疗，Ⅰ、Ⅱ级治疗毒副反应主要为放射性咽部黏膜炎和皮肤放射性损伤，无Ⅲ级及以上的治疗毒副反应发生。3、5年生存率分别为70.6％和57.9％。结论下咽癌患者手术后加放射治疗的毒副反应患者能耐受，取得了较好的生存率。Objective To evaluate the effect and toxicity of adjuvant radiotherapy for patients of hypopharynx cancer after operation, Methods A retrospective review of 32 postoperative patients with clinical stage T2-4N0-2M0 hypopharynx cancer treated with adjuvant radiotherapy between April 1998 and March 2000 in Qilu hospital was performed. All the patients received pharyngolaryngectomy and elective neck dissection, 2-4 weeks after operation a total dose of 55-66 Gy radiotherapy was delivered at the rate of 1.8-2 Gy per fraction. After radiotherapy regular follow-up was undertaken, Treat-related toxicity was observed and overall survival was estimated by the Kaplan-Meier method. Results All the patients completed the protocol therapy successfully, The most common grade Ⅰ and Ⅱ toxicity was mucositis of throat and radiation injury to skin. No grade Ⅲ or higher toxicity was observed, The 3-and 5-year survival rate was 70. 6% and 57.9% ,respectively. Conclusion Adjuvant radiotherapy after operation has lower toxicity which patients can endure. And the overall survival rate is satisfying.

关 键 词：下咽肿瘤 放射疗法 综合疗法 

分 类 号：R73[医药卫生—肿瘤]