Synthesis of a novel tri-antennary galactoside with high hepatocyte targeting  

作　　者：Lei Tang Yong Wu Jiao Lu Zhi Rong Zhang Jin Cheng Yang Li Hai 

机构地区：[1]Key Laboratory of Drug Targeting Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China

出　　处：《Chinese Chemical Letters》2007年第5期513-515,共3页中国化学快报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China （No. 30672537）；Ministry of Education of ER. China （No. 20050610085）.

摘　　要：A novel bifunctional compound carrying duster thiogalactoside as the cell targeting ligands was synthesized for gene delivery to hepatocytes. Tetra-antennary dendr-OMs4 5 was used as a scaffold for the attachment of three galactosides, while the other mesylate end was linked with cholesterol through poly（ethylene glycol） chain. This design provided an effective entry for the synthesis of the bifunctional compound.A novel bifunctional compound carrying duster thiogalactoside as the cell targeting ligands was synthesized for gene delivery to hepatocytes. Tetra-antennary dendr-OMs4 5 was used as a scaffold for the attachment of three galactosides, while the other mesylate end was linked with cholesterol through poly（ethylene glycol） chain. This design provided an effective entry for the synthesis of the bifunctional compound.

关 键 词：Cluster Cholesterylated galactoside Targeting ligand Hepatocyte-specific delivery Gene delivery 

分 类 号：R914.5[医药卫生—药物化学] R945[医药卫生—药学]