以DSS致小鼠溃疡性结肠炎为动物模型呼吸道sIgA为检测指标探讨“肺合大肠”理论的相关途径  

Study the Concrete Channel of the Lung Being Relative to the Large Intestine Theory Through Experiment on Animal with the DSS Causing Mouse UC Model Being the Animal Model and Respiratory sIgA the Test Target

作　　者：方亚利[1] 张登本[2] 邢玉瑞[2] 孙理军[2] 

机构地区：[1]山东中医药大学,山东济南250014 [2]陕西中医学院,陕西咸阳712046

出　　处：《中华中医药学刊》2007年第5期976-979,共4页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:从黏膜免疫角度探讨“肺合大肠”理论的具体相关途径,丰富“肺合大肠”理论的内涵,为溃疡性结肠炎的治疗,提供新的思路。方法:以DSS致小鼠溃疡性结肠炎为动物模型,检测模型组与空白对照组呼吸道灌洗液中分泌性IgA(sIgA)的含量。结果:模型组与空白对照组分泌性IgA(sIgA)含量经统计学处理后,无统计学意义。结论:①本次动物实验设计丰富了“肺合大肠”理论的实验研究方法;②实验结果可能和3种因素的影响有关;③通过本实验探讨动物实验方法存在的问题;④该实验的启示。Objective： Make a thorough inquiry into concrete channel through which the lung being relative to the large intestine theory in mucosal immune. Then, firstly, enrich its conception. Secondly, supply the new therapeutic train of thought for Ulcer Colitis（uc）. Methods： Choose the mouse UC model as the animal model. Test and determine content of slgA in respiratory fluid made by the way of pouring and washing. Results： slgA content between model group and contrast group dosen＇t indicate obvious disparity. The result has not statistical meaning. Conclusion： （1）This experiment design is so different from others as to enrich this theory＇ s experiment study methods. （2）Three facts are probably the causes which lead to the experimental result. （3）Investigate the problems which exist in experimental method on animals. （4） This experiment show some inspiration.

关 键 词：“肺合大肠”理论 DSS 小鼠溃疡性结肠炎 分泌性IGA 动物实验研究 黏膜免疫 

分 类 号：R574[医药卫生—消化系统]