抑郁症的生物学病因和抗抑郁药的研究进展  

Advances in research on biological etiology of depression and the antidepressants

作　　者：沈剑文[1] 梁志健[1] 

机构地区：[1]上海市精神卫生中心药剂科,上海200030

出　　处：《药学服务与研究》2007年第2期94-99,共6页Pharmaceutical Care and Research

摘　　要：抑郁症是一种常见的精神疾病。虽然确切的病因及病理机制尚不清楚,但随着抑郁症的病因病理研究的不断深入,抗抑郁药也有了较快的发展。由于目前的药物起效慢和不良反应多,临床疗效仍不满意,多靶点、多系统共同作用类药物已成为新的研究方向。本文就抑郁症的神经生化机制及新型抗抑郁药的作用特点作一综述。Depression is a very common mental disease. Though the exact etiology and pathogenesis of depression are not clear, antidepressants have been developed quickly with the advance in research on the etiology and pathology of depression. They still can not meet clinical needs with respect to both efficacy and side effects. A diversity of multi-target strategies are proposed for the future generation of successful antidepressants. In this paper, the neurobiological mechanisms of depression and the characteristics of antidepressants are reviewed.

关 键 词：抑郁症 抗抑郁药 神经递质 神经生物学 综述 

分 类 号：R971.43[医药卫生—药品] R749.42[医药卫生—药学]