新城鸡瘟病毒修饰自体肿瘤细胞疫苗在28例中晚期宫颈癌的应用  

Application of New castle Disease Virus-Modified Autologous Tumor Vaccine in 28 Cases with Advanced Cervical Carcinoma

作　　者：蒋联萍[1] 赵玉萍[1] 王弋[1] 

机构地区：[1]温州市第二人民医院温州市肿瘤医院,浙江温州325000

出　　处：《中国肿瘤》2007年第5期386-388,共3页China Cancer

摘　　要：[目的]探讨新城鸡瘟病毒修饰自体肿瘤细胞疫苗(NDV-ATV)在中、晚期宫颈癌治疗中的作用。[方法]28例宫颈癌行NDV-ATV免疫治疗和放射治疗(实验组),30例单纯接受放射治疗(对照组)。采用流式细胞术观察患者在接受免疫治疗前后外周血中CD4+、CD8+、CD4+/CD8+比值变化以及放射治疗的近期疗效、毒副反应等。[结果]实验组28例中、晚期宫颈癌患者经治疗1～2个疗程后,其CD4+、CD4+/CD8+比值较治疗前显著增加(P<0.05),同时CD8+数量较治疗前降低(P<0.05),放射治疗近期疗效较对照组好(P<0.05),毒副反应轻。[结论]新城鸡瘟病毒修饰自体肿瘤细胞疫苗能增强患者免疫功能,对放射治疗有协同作用。[Purpose] To explore the role of New castle disease virus-modified autologous tumor vaccine （NDV-ATV） for treating advanced cervical carcinoma. [Methods] Twenty-eight cases with cervical carcino- ma underwent NDV-ATV immunotherapy combined with radiotherapy （experimental group）, and 30 cases underwent radiotherapy alone（control group）. The changes of CD4^＋, CD8^＋ and CD4^＋/CD8^＋ in the peripherical blood were measured by flow cytometry. Short-term effects of radiotherapy and its side effects were investigated. [Results] After one to two courses of the therapy for 28 cases with advanced cervical carcinoma, the levels of CD4^＋ and ratio of CD4^＋/CD8^＋ significantly increased than those before treatment （P〈0.05）, and CD8^＋ significantly decreased than that before the therapy （P〈0.05）. The short-term effects of radiotherapy in experimental group was better than that in control group （P〈0.05） with mild side effects in former group. [Conclusions] New castle disease virus-modified autologous tumor vaccine （NDV-ATV） enhances the immunity in cervical carcinoma and synergistically with radiotherapy.

关 键 词：新城鸡瘟病毒 自体疫苗 免疫功能 宫颈肿瘤 

分 类 号：R737.33[医药卫生—肿瘤]