十二指肠乳头喷洒利多卡因对ERCP术后胰腺炎发生和血淀粉酶水平的影响  

Effects of Lidocaine Sprayed on the Majou Duodenal Papilla on the Prevention of Post-ercp Pancreatitis and Hyperamylasemia

作　　者：王锋[1] 王琦[1] 李昭宇[1] 

机构地区：[1]宁夏医学院附属医院肝胆外科,银川750004

出　　处：《宁夏医学院学报》2007年第2期127-129,共3页Journal of Ningxia Medical College

摘　　要：目的探讨十二指肠乳头局部喷洒利多卡因对经内镜逆行胰胆管造影(endoscopic retrograde cholangiopan-creatography,ERCP)术后胰腺炎发生和血淀粉酶水平的影响。方法需要接受ERCP手术的112例患者随机分为利多卡因组和对照组,利多卡因组55例,对照组57例。前者在十二指肠乳头插管前给予10mL 1%利多卡因乳头局部喷洒,后者给予生理盐水,比较两组ERCP后胰腺炎和高淀粉酶血症的发生情况。结果利多卡因组术后胰腺炎发生率(3.64%vs 15.79%,P=0.031)和高淀粉酶血症发生率(18.18%vs 40.35%,P=0.01)均明显低于对照组。结论十二指肠乳头局部喷洒利多卡因可以降低ERCP术后胰腺炎和高淀粉酶血症的发生。Objective To evaluate the preventive effects of lidocaine sprayed on the major duodenal papilla on the frequency of post-ERCP pancreatitis and hyperam- ylasemia. Methods A total of 112 patients were recruited. Patients undergoing ERCP were randomly divided into lidocaine group（55 patients） and control group（57 patients） who had 10 mL of 1% lidocaine or normal saline solution sprayed on the major papilla before cannulation. The end point was the incidence of post-ERCP pancreatitis and hyperamylasemia. Resttlts There was no significant difference in basic information , such as age, gender and diagnosis indictions of ERCP between lidocaine group and control group. The frequencies of post-ERCP pancreatitis （3.64% vs 15.79%, P =0.031） and hyperamylasemia （18.18% vs 40.35%, P = 0.01） in lidocaine group were both significantly lower than that in controls. Conclusion The results indicate that lidocaine sprayed on the major papilla can prevent post-ERCP pancreatitis and hyperamylasemia.

关 键 词：利多卡因 经内镜逆行胰胆管造影术 胰腺炎 高淀粉酶血症 预防 

分 类 号：R576[医药卫生—消化系统]