脑胶质瘤BCNU治疗方法的对比研究  

Curative effectiveness of two different methods with BCNU in the treatment of malignant cerebral gliomas after operation

作　　者：赵红军[1] 许红旗[1] 

机构地区：[1]河南省安阳市第一人民医院,455000

出　　处：《临床外科杂志》2007年第4期268-269,共2页Journal of Clinical Surgery

摘　　要：目的比较手术结合瘤腔局部缓释化疗和手术结合静脉化疗治疗脑胶质瘤的效果。方法回顾分析我院2003年2月至2005年4月间胶质瘤病例48例,其中手术结合瘤腔局部缓释化疗治疗胶质瘤20例,设为A组,手术结合静脉化疗治疗胶质瘤28例,设为B组,分别比较两组有效率、中位生存期、1年控制率。结果A、B两组有效率分别为85.0%和53.6%,中位生存时间分别为(49±19.75)周和(36±13.96)周,1年肿瘤控制率分别为85.0%和57.1%,三种指标两组间差异均有统计学意义(P<0.05)。结论手术结合瘤腔缓释化疗比手术结合静脉化疗获得了更为满意的疗效。Objective To compare the curative effectiveness of surgical operation plus sustained - release chemotherapy （SRCT） vs surgical operation plus transvenous chemotherapy in the treatment of patients with malignant Cerebral gliomas （MCG）. Methods Between February 2003 and April 2005,48 eases of MCG were divided into two groups： group A （20 cases） treated with SRCT after operation and group B （28 cases） treated with transvenous chemotherapy after operation. The curative effectiveness, the median survival time and the 1 - year survival rate between the two groups were compared. Results The effectual rate in group A and group B was 85.0 % and 53.6 % respectively. The median survival time in group A and group B was （49 ± 19.75） weeks and （36 ±13.96） weeks respectively. The 1 - year survival rate in group A and group B was 85.0 % and 57.1% respectively. There were significant differences in above parameters between two groups （ P 〈 0.05）. Conclusion The method of operation plus SRCT is more effective than that of operation plus transvenous chemotherapy in MCG.

关 键 词：胶质瘤 化疗 生物蛋白胶 卡氮芥 

分 类 号：R739.4[医药卫生—肿瘤]