槐耳多糖对胃癌患者术后细胞免疫功能影响的研究  

Study of effect of Huai Er on cellular immune function of gastric cancer patients after operation

作　　者：段体德[1] 毕品端[1] 杨策尧[2] 

机构地区：[1]昆明医学院第一附属医院肝胆外科,云南昆明650032 [2]昆明医学院第一附属医院临床医学研究中心,云南昆明650032

出　　处：《云南医药》2007年第2期92-95,共4页Medicine and Pharmacy of Yunnan

摘　　要：目的研究槐耳多糖对胃癌患者术后细胞免疫功能的影响,从细胞水平探讨其免疫调节作用机制,为胃癌的综合治疗寻求更为有效的方法。方法对进展期胃癌根治术患者40例,随机分为手术化疗组(五氟脲嘧啶)和手术实验组(槐耳颗粒金克)各20例,进行治疗,并分别于术前,术后2周,术后6周,术后10周进行T细胞亚群,NK细胞检测。结果胃癌患者术前其细胞免疫功能即存在不同程度的障碍,手术化疗组在术后可加重此种损害,术后6周,10周细胞免疫功能仍然未见恢复好转,手术实验组手术后6周,10周细胞免疫功能CD3+,CD3+CD4+,CD3+CD4+/CD3+CD8+,NK与术后2周比有好转及回升,P<0.05。结论槐耳多糖可提高胃癌患者的细胞免疫功能,具有扶正抗癌作用。Objective To study the anti-tumor effect of Huai Er, a Chinese prepared medicine, on the cellular immune function. Methods Forty cases of post-operative gastric cancer patients were divided into treatment group and control group randomly. Huai Er and 5-Fu were used respectively. Peripheral blood samples in the 40 patients were collected to detect the lymphocyte subsets during pre-operatively, 2 weeks, 6 weeks and 10 weeks after operation, respectively. The data were statistically analyzed by paired samples. Results The CD3^＋, CD3^＋CD4^＋, CD3^＋CD4^＋ /CD3^＋CD8^＋, and NK cells increased remarkably 6 weeks and 10 weeks post-operatively compared with 2 weeks post-operatively （P 〈 0.05） in treatment group. Conclusions Huai Er may produce some anti-tumor effect by improving cellular immune function.

关 键 词：细胞免疫 胃癌 槐耳多糖 

分 类 号：R735.2[医药卫生—肿瘤]