肝素酶:一种新的广谱的肿瘤转移相关抗原在中晚期肿瘤免疫治疗中的作用研究进展  

Heparanase: a new universal metastasis-associated antigen in the immunotherapy for the advanced cancers

作　　者：杨仕明[1] 汤旭东[1] 陈婷[1] 熊震[1] 陈陵[1] 蔡永国[1] 房殿春[1] 

机构地区：[1]中国人民解放军第三军医大学西南医院全军消化病研究所,重庆市400038

出　　处：《世界华人消化杂志》2007年第8期849-854,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30200123;No.30570841

摘　　要：肝素酶(Hpa)是裂解硫酸乙酰肝素蛋白多糖的唯一酶类,能破坏细胞外基质及基底膜,参与肿瘤血管生成,与肿瘤的侵袭转移密切相关．目前的研究表明,Hpa在大多数中晚期肿瘤中都有表达,尤其在转移性肿瘤中强表达,而Hpa表达的下调可以抑制肿瘤细胞的转移,提示Hpa可以作为一种广谱的肿瘤转移相关抗原用于中晚期肿瘤的免疫治疗．Hpa疫苗的开发可望为中晚期肿瘤的治疗开辟新的途径．本文详细综述了Hpa的结构与功能、对肿瘤转移的促进作用及其机制、以及其作为肿瘤转移相关抗原用于中晚期肿瘤免疫治疗的可能性．Heparanase （Hpa） was an endo-β-D-glucuronidase that can cleave heparan sulfate proteoglycans （HSPGs） and has been implicated in tumor angiogenesis and metastasis. It has been reported that Hpa was expressed in almost all the advanced tumors, especially in metastatic tumors, and in contrast, down-regulation of Hpa could inhibit the metastasis of tumors. These results indicated that Hpa could serve as a new universal tumor-metastasis-associated antigen in the immunotherapy for the advanced tumors. Development of Hpa vaccine may establish a new method for the treatment of the advanced tumors. In this review, structure and functions of Hpa and its possibility as a new universal antigen in the immunotherapy of the advanced tumors were discussed.

关 键 词：肝素酶 肿瘤 免疫治疗 硫酸乙酰肝素蛋白多糖 肿瘤转移相关抗原 

分 类 号：R730.5[医药卫生—肿瘤]