血清神经元特异性烯醇化酶与急性脑出血关系的研究  

Study of correlation between serum neuron-specific enolase and acute intracerebral hemorrhage

作　　者：赵明哲[1] 史万英[1] 朱荣彦[1] 闫鹤立[1] 李育臣[2] 

机构地区：[1]石家庄市中心医院神经内科,050011 [2]河北医科大学第三医院神经内科

出　　处：《临床神经病学杂志》2007年第2期134-136,共3页Journal of Clinical Neurology

摘　　要：目的探讨血清神经元特异性烯醇化酶（NSE）与急性脑出血的关系。方法采用酶联免疫吸附法对40例急性脑出血患者血清NSE水平进行动态检测,分析其与脑出血量、神经功能缺损程度评分（NDS）、脑出血部位的关系,并与正常对照组比较。结果脑出血组患者在发病48h内血清NSE水平即明显升高,3-5d达到峰值,6-9d和10-14d时仍明显高于正常对照组（P〈0.01-0.001）;脑出血患者血清NSE水平与出血量及NDS呈正相关（r=0.421,P〈0.01;r=0.415,P〈0.01）;与脑出血部位无明显关系（P〉0.05）。结论急性脑出血患者血清NSE水平明显升高,并且与脑出血量和病情有关。Objective To study the correlation between serum neuron-specific enolase （NSE） and acute intracerebral hemorrhage （ICH）. Methods The serum level of NSE was measured in 40 patients with acute ICH by ELISA and compared with normal control subjects. The relationship between serum NSE level and neurological deficit scores （NDS）, volume and site of hemorrhage were analyzed. Results The serum level of NSE in ICH group increased within 48 hours, peaked at 3 -5 d, obviously higher at 6 -9 d and at 10 - 14 d compared with the control group （P 〈 0.01 - 0. 001 ）. There were positive correlations between the serum NSE level and the volume of hemorrhage （r=0.421, P〈0.01） and NDS （r =0.415, P〈0.01）. Conclusions The level of NSE in serum rises in the patients with acute ICH. It is closely related to the volume of hemorrhage and the condition of disease.

关 键 词：急性脑出血 神经元特异性烯醇化酶 

分 类 号：R743.3[医药卫生—神经病学与精神病学]