C-myc蛋白在脑胶质瘤组织中的表达及意义  

The expression and significance of C-myc in gliomas

作　　者：周任[1] 刘勇[2] 王睿智[1] 吕健[1] 王康敏[3] 赵世平[3] 师蔚[1] 

机构地区：[1]西安交通大学医学院第二附属医院神经外科,陕西西安710004 [2]西安交通大学医学院人体解剖学与组织胚胎学系,陕西西安710061 [3]西安交通大学医学院第二附属医院病理科,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2007年第2期203-204,219,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的探讨C-myc蛋白在脑胶质瘤组织中的表达情况及其与肿瘤恶性程度之间的关系。方法应用免疫组织化学方法检测40例脑胶质瘤组织标本中的C-myc蛋白表达情况。结果C-myc蛋白阳性染色主要定位于脑胶质瘤细胞的胞浆或胞核中,其表达强度与脑胶质瘤的组织学分级相关,随着脑胶质瘤恶性程度的增高,C-myc的表达强度和阳性细胞百分比也随之逐渐增加,各级之间均有显著性差异(P<0.05)。结论C-myc蛋白在脑胶质瘤组织中呈过度表达,并与脑胶质瘤的恶性程度密切相关。Objective To explore the expression of C-myc in gliomas and its clinical significance. Methods The expression of C-myc in 40 cases of gliomas was examined with immunohistochemical technique. The relationship of the expression of C-myc with the histological grades of the gliomas was analyzed. Results C-myc overexpression in the gliomas and the level of the expression were related to the histological grades of the gliomas. With higher malignancy, the expression level increased. The expression of C-myc in the gliomas of different grades was significantly different. Conclusion C-myc overexpression in the gliomas is related to the tumor malignancy.

关 键 词：胶质瘤 C-MYC蛋白 免疫组织化学 

分 类 号：R730.55[医药卫生—肿瘤]