重组人骨形态发生蛋白-7复合体对牙槽骨再生的影响  

Role of Recombinant Human Bone Morphogenetic Protein-7/Gelatin Sponge Complex in Regeneration of Alveolar Bone in Dogs

作　　者：孙杰[1] 卞翠荣[2] 王世立[1] 韩金祥[1] 张维东[3] 李国菊[4] 

机构地区：[1]山东省医药生物技术研究中心,济南250062 [2]山东大学齐鲁医院口腔科,济南250012 [3]山东省医学科学院基础医学研究所实验病理学与生理学研究室,济南250062 [4]山东大学口腔医院放射科,济南250012

出　　处：《中国生物制品学杂志》2007年第4期282-284,共3页Chinese Journal of Biologicals

基　　金：济南市科技局资助项目

摘　　要：目的观察基因重组人骨形态发生蛋白-7(rhBMP-7)与明胶海绵的复合体对犬牙槽骨再生的影响。方法犬拔牙创内植入rhBMP-7与明胶海绵的复合体,以自然愈合拔牙创为对照。于术后2、4、8周分别将犬处死,取拔牙创处牙槽骨标本,行X线和组织学切片检查,观察成骨情况及牙槽骨萎缩情况。结果X线及组织学切片显示实验侧成骨速度及成骨质量明显优于对照侧。结论rhBMP-7与明胶海绵复合体是一种可促进牙槽骨再生的新型生物复合材料。Objective To observe the influence of complex of recombinant human bone morpbogenetic protein-7 （rhBMP-7） and gelatin sponge on the regeneration of alveolar bone in dogs. Methods Implant rhBMP-7/gelatin sponge complex into the extraction sockets of dogs and kill the dogs 2,4 and 8 weeks after implantation respectively. Observe the bone formation and depauperation of alveolar bone by X-ray and histological examinations, using those of the extraction sockets by normal healing as control. Results Both the speed and quality of bone formation of extraction sockets treated by implantation of rhBMP-7/gelatin sponge complex were significantly higher than those by normal healing. Conclusion rhBMP-7/gelatin sponge complex was a novel biological material enhancing the regeneration of alveolar bone.

关 键 词：骨形态发生蛋白 复合体 牙槽骨 再生 

分 类 号：R782.13[医药卫生—口腔医学]