大鼠四氧化二氮中毒后多焦视网膜电图改变  

Features of multifocal electroretinogram of N_2O_4 injected mice at different time

作　　者：仇长宇[1] 胡莲娜[1] 李建中[1] 闫洪欣[1] 罗灵[1] 赵军[1] 李志生[1] 

机构地区：[1]解放军306医院眼科,中国北京市100101

出　　处：《国际眼科杂志》2007年第2期409-410,共2页International Eye Science

基　　金：中国人民解放军总装医药卫生类基金资助(No.yy2003015)~~

摘　　要：目的:研究大鼠在航天推进剂四氧化二氮染毒后多焦视网膜电图改变。方法:正常雄性Winstar大鼠,用15mg四氧化二氮溶液ip染毒,1h及7d检查的大鼠为6～10只,在晚上固定时间进行苯巴比妥钠溶液ip麻醉及多焦视网膜电图检查。用Microsoft Excel自带的统计软件对数据进行分析。结果:四氧化二氮15mg染毒后1h组的大鼠与正常大鼠的MERG的总和波及各环b波的潜伏期的差异具有显著意义(P值0.005～0.034,P<0.05);染毒后7d的大鼠与正常大鼠MERG的总和波及各环b波的潜伏期的差异没有显著意义;两组染毒大鼠与正常大鼠MERG的总和波及各环b波的波幅值的差异均无显著意义。染毒后1h组与染毒后7d组之间的MERG的总和波及各环b波的潜伏期的差异其部分指标具有显著意义(P值0.006～0.017,P<0.05),其余部分指标的差异无显著意义;而两组之间波幅值的差异无显著意义。结论:1h及7d四氧化二氮染毒大鼠的MERG潜伏期的差异其部分指标具有显著意义,MERG总和波及各环b波潜伏期有不同程度的差异,其影响随着时间延长而减弱。AIM： To record rnultifocal electroretinogram from N2O4 injected mice at different time. In order to provide a found for further study. METHODS： Six to Ten mice which were injected by N2O4 in each group were studied for recording multifocal electroretinogram in the same time in the evening after different time from injected. RESULTS： The latency and amplitude density of b wave of each ring of multifocal electroretinogram was steady. The latency of b wave of each ring of multifocal electroretinogram of each group varies to each other. But the difference of the amplitude of b wave of multifocal electroretinogram of each ring between each group had no significance. CONCLUSION： Recording multifocal electroretinogram of N2O4 injected mice has wide use in science and dinic research.

关 键 词：多焦 视网膜电图 大鼠 四氧化二氮 

分 类 号：R770.4[医药卫生—眼科]