TNF与糖尿病视网膜病变  

Tumor necrosis factor and diabetic retinopathy

作　　者：姜文敏[1] 唐罗生[1] 

机构地区：[1]中南大学湘雅二医院眼科,中国湖南省长沙市410011

出　　处：《国际眼科杂志》2007年第2期481-484,共4页International Eye Science

摘　　要：系统性微血管病变和糖尿病视网膜病变(diabetic retinopathy,DRP)是糖尿病患者致死性及致盲性的根源,然而其具体机制尚不十分清楚。推测免疫和炎症反应可能涉及其病程及病理进展,尤其对于增殖性视网膜病变(perliferative diabetic retinopathy,PDR),因而有人提出DRP是一种炎症性疾病。本文就炎症反应最具代表性的细胞因子之一——肿瘤坏死因子(tumor necrosis factor,TNF)及其在糖尿病视网膜病变中的可能作用加以综述。Systemic microvascular disease and diabetic retinopathy （DRP） are currently the principal causes of morbidity and mortality in patients with diabetes mellitus, yet the mechanism behind it has not been fully understood. It has been demonstrated that immune phenomena and inflammatory reactions might be involved in the pathogenesis and progression, espedally in proliferative DRP. Therefore it has been indicating that DRP is an inflammatory disease. The present paper reviews one of the most representative cell factors, tumor necrosis factor （TNF） and its functions in DRP.

关 键 词：糖尿病视网膜病变 肿瘤坏死因子 增殖性视网膜病变 炎症反应 

分 类 号：R774.1[医药卫生—眼科]