Immunoscintigraphy of local recurrent rectal cancer with^(99m)Tc-labeled anti-CEA monoclonal antibody CL58  

作　　者：Yun-Feng Yao Zhi Yang Zhen-Fu Li Jin Gu 

机构地区：[1]Peking University School of Ontology, Beijing 100036, China

出　　处：《World Journal of Gastroenterology》2007年第12期1841-1846,共6页世界胃肠病学杂志（英文版）

基　　金：Supported by National High-Tech R&D Program of China (863 Program), No. 2004AA215270

摘　　要：AIM: To explore a specific diagnostic method for local recurrent rectal cancer.METHODS: Immunoscintigraphy with 99mTc-labeled anti-CEA monoclonal antibody (MoAb) CL-58 was performed for patients suspected of having a postoperative local recurrent rectal cancer and the findings were compared with the results of conventional imaging and pathology.RESULTS: A total of 36 patients with a suspected local recurrent rectal cancer underwent immunoscintigraphy with 99mTc-conjugated CL58. Local recurrence of rectal cancer was identified in 31 patients and established in 30 during operation, endoscopy and pathological examination. No local recurrence was found in 5 patients without specific accumulation of 99mTc during the follow-up. Immunoscintigraphy had a positive rate of 86.11%, a specificity of 83.33%, and a sensitivity of 100%.CONCLUSION: Immunoscintigraphy has a highly specific and predictive value for detecting local recurrent rectal cancer, especially after abdominal perineal resection (APR).AIM： To explore a specific diagnostic method for local recurrent rectal cancer. METHODS： Immunoscintigraphy with ^99mTc-labeled anti- CEA monoclonal antibody （MoAb） CL-58 was performed for patients suspected of having a postoperative local recurrent rectal cancer and the findings were compared with the results of conventional imaging and pathology. RESULTS： A total of 36 patients with a suspected local recurrent rectal cancer underwent immunoscintigraphy with ^99mTc-conjugated CL58. Local recurrence of rectal cancer was identified in 31 patients and established in 30 during operation, endoscopy and pathological examination. No local recurrence was found in 5 patients without specific accumulation of ^99mTc during the followup. Immunoscintigraphy had a positive rate of 86.11%, a specificity of 83.33%, and a sensitivity of 100%. CONCLUSION： Immunoscintigraphy has a highly specific and predictive value for detecting local recurrent rectal cancer, especially after abdominal perineal resection （APR）.

关 键 词：IMMUNOSCINTIGRAPHY Rectal cancer RECURRENCE Monoclonal antibody 

分 类 号：R735.37[医药卫生—肿瘤] R730.44[医药卫生—临床医学]