结内边缘区B细胞淋巴瘤临床病理观察  

Nodal marginal zone B-cell lymphoma: a clinicopathological observation

作　　者：何春燕[1] 卢志达[1] 杨冬梅[1] 刘红刚[1] 

机构地区：[1]首都医科大学附属北京同仁医院病理科,北京100730

出　　处：《诊断病理学杂志》2007年第2期101-104,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的提高对结内边缘区B细胞淋巴瘤(NMZL)的认识。方法对1例结内NMZL进行临床、病理组织学和免疫组化观察,复习相关文献。结果患者男性,71岁,腹股沟淋巴结肿大起病。组织病变有突出的单核样B细胞增生和反滤泡结构,晚期呈弥漫性结节状和大细胞化,瘤细胞表达成熟B细胞免疫表型:CD20、CD79a(+),CD5、CD10和CD23(-),bcl-2(+)。历时6年,行23个疗程化疗,病情反复复发,终致累及全身淋巴结、骨髓和外周血。结论NMZL为少见的独立实体,原发于淋巴结的低度恶性B细胞淋巴瘤。临床表现为外周淋巴结肿大,惰性经过。Objective To improve the acquaintance with nodal marginal zone B-cell lymphoma （NMZL）. Methods Clinical data, pathologic changes and immunohistochemical findings were observed in one case of NMZL, with review of the related hterature. Results A patient was 71 year-old man with the left inguinal lymph nodal enlargement. Histologically there were prominent monocytoid B cell proliferation forming inverse follicular pattern, which showed diffuse nodal and transformed large cells. Immunostaining of tumor cells were positive for CD20, CD79a, bcl-2, and negative for CD5, CD10, CD23. Pathological diagnosis of the NMZL was made. During the follow-up period of 6 years, 23 courses of chemotherapy were given, but the disease could not be controlled and finally most of the lymph nodes and bone marrow and peripheral blood were involved. Conclusion NMZL is a rare and low malignant B cell lymphoma and primarily involves lymph nodes, and it is a different entity from other samll cell lymphomas. Its clinical course appears indolent.

关 键 词：淋巴结边缘区 淋巴瘤 边缘区淋巴瘤 

分 类 号：R733.7[医药卫生—肿瘤]