氯化锂-匹罗卡品诱发大鼠癫痫持续状态后脑内c-fos蛋白表达的动态观察  

Expression of C-fos Protein in Rats with Status with Epilepticus Induced by Lithium- Pilocarpine

作　　者：薛国芳[1] 郑辑英[1] 李光来[1] 王荔[1] 刘勇[2] 

机构地区：[1]山西医科大学第二医院 [2]日本国立弘前大学医学部

出　　处：《中西医结合心脑血管病杂志》2007年第5期419-420,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的在氯化锂-匹罗卡品诱发癫痫持续状态模型中观察c-fos蛋白表达的时程变化。方法采用氯化锂-匹罗卡品诱发癫痫持续状态大鼠模型,观察大鼠的行为改变,并用免疫组化方法观察癫痫持续状态后不同时间点脑内c-fos蛋白表达的变化。结果癫痫持续状态后6h,1d时脑内c-fos蛋白表达最高,3d时表达次之,7d时极少数表达并接近对照组表达水平。结论癫痫持续状态后脑内c-fos蛋白表达持续较长时间;在此时期应给予干预措施,以减低脑内神经元损伤可能。Objective To study the time course of c- fos protein expression in rats with status epilepticus （SE） induced by LithiumPilocarpine, Methods SE model was induced by lithium- pilocarpine in rats. The behaviors of rats were observed and time course of the c- fos expression were studied by immunohistochemical staining. Results The c- fos protein expression was significant after SIS 6 hour and lday, obvious after SE 3 day. Conclusion The c- fos protein expression during SIS would lasted for a long time. Some measurements should be taken to decrease the damage of neurons.

关 键 词：氯化锂-匹罗卡品 癫痫持续状态 c—fos蛋白 

分 类 号：R742.1[医药卫生—神经病学与精神病学]