伽玛刀治疗垂体腺瘤126例的临床分析  

Gamma Knife treatment for 126 cases with pituitary adenoma

作　　者：董连强[1] 胡泽勇[1] 周文静[1] 夏廷毅[1] 程钢戈[1] 黄永安[1] 

机构地区：[1]北京空军总医院神经外科,北京100036

出　　处：《立体定向和功能性神经外科杂志》2007年第2期100-101,共2页Chinese Journal of Stereotactic and Functional Neurosurgery

摘　　要：目的 评价伽玛刀治疗垂体腺瘤的疗效和并发症。方法 对2000年8月至2005年12月间伽玛刀治疗垂体腺瘤并有完整临床资料。病人年龄15～76岁，肿瘤最大径＜10mm68例、10-20mm56例、〉20mm^2例，伽玛刀治疗剂处方量为15-30Gy、50％～65％等剂量曲线。结果 随访1～6年，肿瘤消失75例，肿瘤缩小28例，肿瘤无变化15例，肿瘤继续增大8例。肿瘤生长控制率93．6％（118／126）；激素水平恢复正常率63％（49／78），垂体功能低下发生率为15％，因肿瘤复发或激素水平未恢复再行肿瘤切除术5例。结论 伽玛刀治疗垂体腺瘤，能控制垂体腺瘤肿瘤生长，可恢复垂体内分泌功能异常改变。Objective To estimate the effect and complications of Gamma Knife treatment for pituitary adenoma. Methods To retrospectively analysis the follow-up data of 126 cases with pituitary adenoma who had been treatment with Gamma Knife. Patients are 15 to 76 years old. There were 68 cases with tumour diameter 〈1cm, 56 cases with tumour diameter 1〈2cm, 2 cases with tumour diameter 〉2cm. The prescribed doses of the treatments were 15-30Gy with 50-65% isodose curves. Results Follow-up duration is 1-6 years. The tumour disappeared in 75 cases, shrunk in 28 cases, stayed in the same in 15 cases, recurrent in 8 cases. The control rate of tumour growth was 93. 6%（118/126）. The recovery rate of hormone level was 81% （63/ 78）. The incidence rate of pituitary hypofunction was （3/126）. The tumour had been operated in 5 cases due to tumour recurrent or hormone level abnormal. Conclusion Gamma Knife treatment, as non-traumatic operation, is a safe and effective method to control the tumour growth and to recover the hormone level of pituitary.

关 键 词：伽玛刀 垂体腺瘤 内分泌异常 

分 类 号：R739.41[医药卫生—肿瘤]