冷冻治疗兔VX_2肝癌的CT评价  

CT Evaluation of Liver VX_2 Carcinoma Treated with Cryoablation in a Rabbit Model

作　　者：叶彤[1] 王志明[2] 曾蒙苏[1] 陆秀良[1] 陆怡[1] 冯豪[1] 顾君英[1] 张来[1] 

机构地区：[1]复旦大学附属中山医院放射科,上海200032 [2]复旦大学附属中山医院肝癌研究所,上海200032

出　　处：《实用放射学杂志》2007年第4期433-436,共4页Journal of Practical Radiology

摘　　要：目的探讨CT在评价肝癌冷冻治疗疗效中的作用。方法20只新西兰大白兔随机分为对照组(n=10)和氩氦冷冻组(n=10),在肝脏接种VX2肿瘤后第14天分别给予假手术和氩氦冷冻,干预后第7、14、28、42天行CT平扫和双期增强检查,观察2组肿瘤体积和CT动态表现,并比较2组肝内转移有无差异。结果干预后第42天,氩氦冷冻组肿瘤体积(387.68±291.30)mm3明显小于对照组(50872.29±7199.62)mm3。对照组肿瘤呈不规则混杂强化,氩氦冷冻组冷冻区边缘早期呈薄壁环形强化,随后逐渐减弱消失,而中心无强化。氩氦冷冻组肝内转移率(30%)明显低于对照组(100%)。结论兔VX2肝癌氩氦冷冻后CT表现为肿瘤彻底损毁,同时肝内转移减少。CT可作为评价肝癌冷冻治疗疗效的有效手段。Objective To investigate the value of CT in evaluating the therapeutic effect of liver cancer with Argon - Helium cryoablation. Methods 20 New Zealand white rabbits were divided randomly into 2 groups ： control group（ n = 10） and cryotherapy group （ n = 10 ） and implanted with VX2 carcinoma in the liver. The two groups were treated with sham operation or Argon - Helium cryoablation 14 days after implantation. Nonenhanced and dual - phase contrast - enhanced CT scans were performed 7, 14, 28 and 42 days after treatment. The volumes and the CT manifestations of VX2 carcinoma in two groups were observed and the metastatic rate of two groups within liver was compared. Results The volume of cryoleision in cryotherapy group was significantly smaller than that of VX2 carcinoma in control group 42 days after treatment[ （387.68 ± 291.30 ） mm^3 versus （ 50872.29 ± 7199.62 ） mm^3 , P 〈 0.01 ]. The VX2 carcinoma in control group exhibited irregular mixed enhancement. In cryotherapy group, the margin of cryolesion exhibited thin circular enhancement in early stage and the extent of such enhancement decreased gradually and disapeared finally, while the center of cryolesion exhibited no enhancement all the time. The liver metastatic rate in eryotherapy group was significantly lower compared with that in control group （ 30% versus 100% , P 〈 0.01 ）. Conclusion CT demonstrated that VX2 carcinoma was completed destroyed and liver metastasis was reduced after Argon - Helium cryoablation. CT is valuable in assessing the therapeutic effect of Argon - Helium cryoablation for liver cancer.

关 键 词：肝肿瘤 冷冻治疗 体层摄影术 X线计算机 动物 实验 

分 类 号：R735.7[医药卫生—肿瘤] R814.42[医药卫生—临床医学]