用优化的基于体素的形态学方法研究初发精神分裂症患者脑结构的MRI特征  

An optimized voxel-based morphometry MRI study of the brain in patients with first episode schizophrenia

作　　者：吕粟[1] 欧阳络[2] 黄晓琦[1] 邓伟[3] 唐鹤涵[1] 蒋莉君[3] 李涛[3] 龚启勇[1] 

机构地区：[1]四川大学华西医院放射科 [2]电子科技大学生命科学院 [3]四川大学华西心理卫生中心

出　　处：《中华放射学杂志》2007年第5期495-498,共4页Chinese Journal of Radiology

基　　金：教育部“新世纪优秀人才支持计划”(NCET-04-0886).

摘　　要：目的运用优化的基于体素的形态学研究(VBM),探索中国汉族人群精神分裂症患者与正常人脑结构之间的差异。方法运用高场强(3.0 T)MR 扫描仪分别采集13例初发且未经治疗的精神分裂症患者和13名年龄、性别、利手配对的正常人(对照组)的高分辨 T_1WI。采用优化的VBM 方法处理所有数据,最后经两样本配对 t 检验,比较2组间的脑灰质密度和灰质体积的差别。结果采用国际通用的统计参数图表示。结果精神分裂症患者的脑灰质体积较对照组缩小、密度较对照组广泛降低。这些区域主要集中于脑双侧颞叶和额叶区域,包括双侧额中回、双侧岛叶等区域,另一些灰质密度降低区散在分布于脑顶叶、枕叶及小脑区域。结论优化的 VBM 可能是一种自动的,有效的研究精神分裂症患者脑结构的方法;初发精神分裂症患者的脑灰质密度较正常人广泛降低,体积较正常人缩小。Objective To evaluate the structural differences between patients with first episode schizophrenia and normal controls using optimized voxel-based morphometry （VBM） study. Methods High resolution T1 weighted images were obtained using 3.0 T MR from 13 first-episode, untreated schizophrenia and 13 age, sex, handedness matched normal controls. Images were preprocessed by employing the optimized VBM and two sample t-test was used to detect differences between patients and normal controls with respect to both density and volume of gray matter in the brain. Results Patients with schizophrenia had significant lower gray matter density and gray matter volume generally distributed among bilateral hemispheres, especially in bilateral frontal and temporal lobes. However, no significant increase of gray matter density and gray matter volume was observed in these patients. Conclusions Optimized voxel-based morphometry study is an automatic and effective method to study psychological diseases such as schizophrenia. Compared with normal controls, patients with schizophrenia had significantly lower gray matter density and gray matter volume across the bilateral hemispheres.

关 键 词：精神分裂症 磁共振成像 脑 

分 类 号：R749.3[医药卫生—神经病学与精神病学]