大孔吸附树脂对川芎中阿魏酸及总酚酸的分离纯化  

Separation and purification of forulic acid and total phenolic acid from Ligusticum chuanxiong Hort by macroporous resins

作　　者：李文兰[1] 范玉奇[1] 季宇彬[1] 王艳萍[1] 赵瑛[1] 

机构地区：[1]哈尔滨商业大学药物研究所博士后科研工作站,哈尔滨150076

出　　处：《中国新药杂志》2007年第9期701-705,共5页Chinese Journal of New Drugs

基　　金：黑龙江省科技厅攻关项目(GC03C614-1)

摘　　要：目的:研究D-101大孔吸附树脂分离纯化川芎中阿魏酸及总酚酸的工艺条件及参数。方法:以阿魏酸及总酚酸的吸附容量和洗脱率为考察指标,研究大孔吸附树脂分离纯化的吸附性能和洗脱参数。结果:D-101大孔树脂对阿魏酸的吸附容量为4．93mg·g^(-1),对总酚酸的吸附容量为51．3mg·g^(-1);洗脱率阿魏酸为96．3％,总酚酸为96．7％。终产品中总酚酸的含量可达51．7％。结论:采用本法分离纯化川芎中阿魏酸及川芎总酚酸是可行的。Objective：To optimize the technical parameters of separation and purification of forulic acid and total phenolic acid from Ligusticum chuanxiong Hort by macroporous resins. Methods：Based on absorptive capacity and elution efficiency of forulic and phenolic acids, the conditions to separate and purify forulic acid and total phenolic acid by macroporous resins were optimized. Results：The optimal resin parameters were assumed as absorptive capacity of 4.93 and 51.3 mg·g^-1 for forulic acid and total phenolic acid, respectively, the elution efficiency of 96.3% and 96.7% for forulic acid and total phenolic acid, respectively, and the purity of total phenolic acid of 51.7%. Conclusion：The optimal condition to separate and purify forulic acid and total phenolic acid from Ligusticum chuanxiong Hort by macroporous resin was feasible.

关 键 词：大孔吸附树脂 阿魏酸 总酚酸 分离纯化 

分 类 号：R284.2[医药卫生—中药学] R972[医药卫生—中医学]