生长激素/胰岛素样生长因子1与阿尔茨海默病  

Growth hormone/insulin-like growth factor 1 and Alzheimer's disease

作　　者：张婷[1] 孙曼霁[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《生命科学》2007年第2期208-213,共6页Chinese Bulletin of Life Sciences

基　　金：中国博士后科学基金资助

摘　　要：生长激素/胰岛素样生长因子-1(GH/IGF-1)轴的合成、分泌、调节及生物学活性与阿尔茨海默病(AD)有密切关系。生长激素(GH)的合成和分泌受生长激素释放激素(GHRH)正向调节。GH/IGF-1轴活性下降导致一系列生理功能变化。GH/IGF-1缺乏可引起衰老及神经退行性变(AD)而导致认知功能的下降,相应激素的补给可以抑制或逆转这种认知障碍。越来越多的证据表明:GH/IGF-1参与AD型痴呆病理过程,对AD有很好的治疗应用前景。本文就生长激素/胰岛素样生长因子1在AD发病中的机理和药理学研究做一综述。The synthesis, secretion, regulation and biological activity of the growth hormone （GH） / insulin-like growth factor- 1 （IGF-1） play important parts in the development of Alzheimer＇s disease （AD）. The synthesis and secretion are regulated by the stimulants, the GH-releasing hormone （GHRH）. Decrement of the activity of the somatotrophic axis causes a series of changes of physiological functions. The deficiency of GH/IGF-1 results in aging and decline of cognition. Supplementation of the related hormones will protect or reverse the cognitive deficits. The evidence available strongly indicates that GH / IGF-1 therapy in Alzheimer＇s dementia may be addressing pathogenic processes. The role of GH/IGF-1 in the development of Alzheimer＇s disease and pharmacological research are reviewed

关 键 词：生长激素 胰岛素样生长因子1 阿尔茨海默病 

分 类 号：R743[医药卫生—神经病学与精神病学] Q575.11[医药卫生—临床医学]