HPLC法测定氨咖黄敏胶囊中对乙酰氨基酚与咖啡因的含量  

Determination of Paracetamol and Caffeine in Ankahuangmin Capsule by HPLC

作　　者：赵雪娥 伍蓉 万莉 

机构地区：[1]重庆市万州区药品检验所,万州404000

出　　处：《中国药品标准》2007年第1期49-51,共3页Drug Standards of China

摘　　要：目的:建立一种用HPLC法测定氨咖黄敏胶囊中对乙酰氨基酚和咖啡因含量的方法。方法:采用C18柱,以甲醇-水(33∶67)为流动相,检测波长为215nm,流速为1.0ml/min。结果:样品中两种成分完全分离且线性关系良好,对乙酰氨基酚和咖啡因的加样回收率分别为99.3%和100.2%。结论:本法操作简单,结果准确,可以有效地控制质量。Objective：To establish a method for determining the contents in Ankahuangmin Capsule by HPLC. Methods：Using C18 column, methanol-water （33 ： 67） as mobile phase, flow rate was 1.0ml/min, wavelength of detector was 215nm. Result： Two components were completely separated and determined. The average recoveries were 99.3% for paracetamol and 100. 20% for caffeine, respectively. Conclusions：This method is simple and convenient in operation. It is accurate and very suitable for the quality control.

关 键 词：对乙酰氨基酚 咖啡因 HPLC 

分 类 号：R291.2[医药卫生—民族医学]