慢性中性粒细胞白血病诊断探讨  

Study on diagnosis of chronic neutrophilic leukemia

作　　者：陈石[1] 李德高[2] 

机构地区：[1]解放军总医院309临床部血液科,北京100091 [2]北京协和医院血液科

出　　处：《临床血液学杂志》2007年第3期141-142,共2页Journal of Clinical Hematology

摘　　要：目的:探讨慢性中性粒细胞白血病(CNL)的诊断方法。方法:分析7例CNL的临床及实验室检查特征。结果:7例患者年龄54～86岁,血红蛋白95～146g/L,外周血分类中性分叶核粒细胞比例84%～95%,WBC总数(15～125)×109/L,Ph1染色体阴性,BCR/ABL融合基因阴性,临床表现为乏力,低热。结论:CNL是一种少见类型白血病,必须与其他慢性白血病相鉴别,如慢性粒细胞白血病(CML)、不典型慢性粒细胞白血病(aCML)、慢性粒-单核细胞白血病(CMMOL)等,CNL碱性磷酸酶积分明显增高,Ph1染色体及BCR/ABL融合基因阴性,可作为其鉴别诊断的依据。Objective：To study the diagnosis of Chronic neutophilic leukemia（CNL）. Method：Clinical characteristics and laboratory data from 7 CNL patients were analyzed. Result：Age range： 54～86 year old, Haemoglobin at 96～146 g/L, the proportion of neutrocyte in peripheral blood：84～95%, amount of WBCt 15～125×10^9/L, Ph^1 chromosome and BCR/ABL fusion gene were all negative, and all the patients manifested fatigue and low fever. Conclution：CNL is a rare type of chronic leukemia, and must be differentiated from other chronic leukemia, such as CML, aCNL,CMMOL, etc. In CNL, neutrophil alkaline phosphatase score increases, Ph^1 chromosome and BCR/ABL fusion gene are all negatives, these can be used as a basis in differential diagnosis.

关 键 词：白血病 粒细胞性 慢性 诊断 

分 类 号：R733.72[医药卫生—肿瘤]