紫伪翼手参中4个甾醇苷的分离鉴定  

Isolation and structural elucidation of four steroidal glycosides from the sea cucumber Pseudocolochirus violaceus

作　　者：张淑瑜[1,2] 易杨华[1] 汤海峰[3] 刘世君[2] 张卫星[2] 胡冠时[2] 

机构地区：[1]第二军医大学药学院海洋药物研究中心 [2]济南军区总医院药剂科,山东济南250031 [3]第四军医大学西京医院药剂科

出　　处：《中国海洋药物》2007年第2期14-18,共5页Chinese Journal of Marine Drugs

摘　　要：目的研究中国南海紫伪翼手参的化学成分。方法应用多种色谱技术分离,运用波谱分析和化学方法鉴定化合物的结构。结果分离得到4个甾醇苷单体并分别鉴定为:24-甲基-5α-胆甾烷-7,22Z-二烯-3β-O-β- D-吡喃木糖苷(I),24-甲基-5α胆甾烷-7,24(28)-二烯-3β-O-β-D-吡喃木糖苷(Ⅱ),24-甲基-5α-胆甾烷-7-烯- 3β-β-D-吡喃木糖苷(Ⅲ)和24-乙基-5α-胆甾烷-7-烯-3β-O-β-D-吡喃木糖苷(Ⅳ)。结论4个化合物均为首次从海参中获得单体。Objective To study the chemical constituents of the sea cucumber Pseudocolochirus violaceus collected from the South China Sea. Methods The compounds were isolated and purified by multi-chromatography and their structures were elucidated based on spectral analysis and chemical evidence. Results Four steroidal glycosides were obtained and identified as： 24-methyl-5α-cholesta-7, 22Z-diene-3β-O-β-D-xylopyranoside （ Ⅰ ）, 24-methyl-5α-cholesta-7, 24 （28）-diene-3β-O-β-D-xylopyrano-side （ Ⅱ ）, 24-methyl-5 α-cholesta-7-ene-3β-O-β-D-xylopyranoside （ Ⅲ ） and 24-ethyl-5α-cholesta-7-ene-3β-O-β-D-xylopyranoside （ Ⅳ ）. Conclusion All the compounds are first reported as pure steroidal glycosides isolated from sea cucumbers.

关 键 词：海参 紫伪翼手参 甾醇苷 分离 结构鉴定 

分 类 号：Q959.269.06[生物学—动物学] R917[医药卫生—药物分析学]