The tyrosinase gene family and albinism in fish  

作　　者：王家庆 侯林 张瑞锋 赵欣涛 姜丽娟 孙文静 安家璐 李晓燕 

机构地区：[1]College of Life Science, Liaoning Normal University

出　　处：《Chinese Journal of Oceanology and Limnology》2007年第2期191-198,共8页中国海洋湖沼学报（英文版）

基　　金：NSFC (No. 30271035)

摘　　要：Tyrosinase exists universally in organisms and is a characteristic enzyme of melanocytes. Tyrosinase family genes in vertebrates consist of 3 related members; tyrosinase （TYR, Tyr）, tyro sinase-related protein-1 （TRP-1, Tyrp 1）, and tyro sinase-related protein-2 （TRP-2, Tyrp2, Dct）. These proteins catalyze melanin biosynthesis in pigment cells and play important roles in determining vertebrate coloration. Transcription of the TYR and TRP genes is useful for studying neural crest and optic vesicle cell migration and differentiation during emblyogenesis and important in pigment rescue in fish. In this paper, the structure of gene and protein molecular evolution, function and roles of the TYR family in fish were reviewed.Tyrosinase exists universally in organisms and is a characteristic enzyme of melanocytes. Tyrosinase family genes in vertebrates consist of 3 related members; tyrosinase (TYR, Tyr), tyrosinase-related protein-1 (TRP-1, Tyrp1), and tyrosinase-related protein-2 (TRP-2, Tyrp2, Dct). These proteins catalyze melanin biosynthesis in pigment cells and play important roles in determining vertebrate coloration. Transcription of the TYR and TRP genes is useful for studying neural crest and optic vesicle cell migration and differentiation during embryogenesis and important in pigment rescue in fish. In this paper, the structure of gene and protein molecular evolution, function and roles of the TYR family in fish were reviewed.

关 键 词：FISH tyrosinase gene family molecular evolution TRANSGENE ALBINISM 

分 类 号：Q953[生物学—动物学]