脊髓多发性硬化的MR扩散成像应用  

Diffusion MRI on spinal multiple sclerosis

作　　者：邹智彤[1] 马林[1] 

机构地区：[1]中国人民解放军总医院放射诊断科,北京100853

出　　处：《中国医学影像技术》2007年第4期630-633,共4页Chinese Journal of Medical Imaging Technology

摘　　要：多发性硬化是中枢神经系统慢性炎性脱髓鞘疾病,常规MR成像已能够敏感地探测病变及其随时间所发生的变化,但它不能可靠地描述和量化病变内及其周围的异常改变,而且活动期和静止期病变表现相似。MR扩散成像能够区分活动期和静止期的病变,量化脊髓内病变进展程度,提供组织受损程度的量化信息,同时有助于显示病变的动态变化、治疗后的反应、描述MS病变的进展,从而有利于研究MS不同表现型疾病的进展。本文回顾和介绍MS斑块病理改变及与MRI表现间的联系,并阐述MR扩散成像技术在脊髓MS的应用。Multiple sclerosis （MS） is a chronic inflammatory demyelinating disease that is heterogeneous and has an unpredictable clinical course. In multiple sclerosis （MS）, the conventional magnetic resonance imaging （MRI） has proven to be sensitive for detecting lesions and their evolution over time. However, the conventional MRI can not reliably characterize and quantify the activity within and outside such lesions. Quiescent and active lesions may have a similar appearance. Diffusion MRI is able to discriminate active from inactive lesions and quantify the severity of on-going spinal cord damage in MS, providing quantitative information on the extent of tissue damage. Diffusion MRI could, therefore, help characterize disease dynamics, response to therapy and explain the accumulation of disability. This may also be useful for research on how the disease progresses among different phenotypes. This review focuses on the current knowledge of the pathologic course and neurodegenerative elements of the multiple sclerosis plaques, the relationship between the pathology and MRI. Finally the review summarizes the major contributions made by diffusion MR techniques in the understanding of MS evolution.

关 键 词：多发性硬化 脊髓 扩散加权成像 扩散张量成像 

分 类 号：R744.51[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]