^(99m)Tc-HL91显像与分化型甲状腺癌清甲后复发的关系研究  

Research on relationship between ^(99m)Tc-HL91 scanning and recurrence of differentiated thyroid carcinoma after complete thyroidectom

作　　者：赵国庆[1] 高凤彤[1] 赵劼[1] 孙辉[1] 马庆杰[1] 

机构地区：[1]吉林大学中日联谊医院,吉林长春130033

出　　处：《中国老年学杂志》2007年第9期857-859,共3页Chinese Journal of Gerontology

摘　　要：目的探讨分化型甲状腺癌原发灶摄取99mTc-HL91的能力与其术后清甲治疗成功后复发的关系。方法173例分化型甲状腺癌患者术前行99mTc-HL91双时相甲状腺局部静态显像,利用感兴趣区技术,分别计算99mTc-HL91早期及延迟T/N比值。根据术后清甲治疗成功后Tg、TgAb、B超、X线及全身131I显像随访结果,将患者分为复发组和无复发组,并对两组结果进行统计学分析。结果(1)99mTc-HL91延迟显像较早期显像对分化型甲状腺癌原发灶检出率高(P<0.05)。(2)分化型甲状腺癌99mTc-HL91延迟显像T/N比值较早期显像升高(P<0.05),并与病理类型无关(P>0.05)。(3)分化型甲状腺癌清甲治疗成功后3年内复发率为5.20%,不同病理类型患者复发率组间差异无显著性(P>0.05)。不同病理类型患者99mTc-HL91早期及延迟显像T/N比值均为复发组高于无复发组(P<0.05)。结论99mTc-HL91显像能灵敏的探测到分化型甲状腺癌病灶的乏氧组织并确定其乏氧程度,同时其早期及延迟T/N比值与分化型甲状腺癌术后清甲治疗成功后复发关系密切。Objective To evaluate the relationship between ^99mTc-HL91 scanning results and recurrence of differentiated thyroid carcinoma （DTC） after complete thyroidectom. Methods 173 cases of DTC received ^99mTc-HL91 focal two-phase static imaging before operation to calculate T/N ratios in ^99mTc-HL91 early and delayed imaging stages through region of interest （ROI） technique. The patients were divided into recurrence group and non-recurrence group after thyroidectom according to the follow-up detecting data of Tg, TgAb, B-mode ultrasonography, X-ray scanning and global ^131I imaging to analyze. Results ①The detecting positive rates of DTC primary focal sites through ^99mTc-HL91 early stage imaging were significantly higher （ P 〈 0.05 ）. ②T/N ratios in ^99mTc-HL91 early stage imaging were obviously higher （P 〈 0.05 ）. And the pathological type variety showed no significant impact on T/N ratio （ P 〉 0. 05 ）. ③The 3 year recurrence rate of different type DTC after thyroidectom was about 5.20%, having no significances among different pathological types （ P 〉 0. 05 ）. However, T/N ratios in different pathological types with 9^99mTc-HL91 early and delayed imaging showed higher recurrence rates compared with those in non-recurrence group （P 〈0. 05）. Conclusions ^99mTc-HL91 imaging could sensitively indicate hypoxia tissues and hypoxia extent in DTC. The T/N ratio detected through ^99mTc-HL91 early and delayed imaging has close relationship with DTC recurrence, which has value for further exploration.

关 键 词：分化型甲状腺癌 复发 HL91 

分 类 号：R736.1[医药卫生—肿瘤]