胰腺腺泡细胞凋亡与急性胰腺炎及其治疗策略  

Relationship between pancreatic acinar cell apoptosis and acute pancreatitis and the therapeutic strategy for acute pancreatitis

作　　者：张桂信[1] 陈海龙[1] 宫爱霞[2] 张利[3] 

机构地区：[1]大连医科大学附属第一医院普外科,辽宁省大连市116011 [2]大连医科大学附属第一医院消化内科,辽宁省大连市116011 [3]大连市中心医院中心实验室,辽宁省大连市116033

出　　处：《世界华人消化杂志》2007年第10期1115-1120,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30271667~~

摘　　要：细胞凋亡是由基因控制的细胞自主的有序的死亡,包含了复杂的调控机制,与细胞坏死有着本质区别,不引起炎症刺激．在实验性及临床急性胰腺炎中均观察到胰腺腺泡细胞的凋亡,研究表明其可能是机体有利的保护性反应．与病情严重程度呈负相关关系．本文总结了近年来对急性胰腺炎胰腺腺泡细胞凋亡机制的研究进展,并对治疗方面的相关研究和探索进行了归纳和阐述．Being a kind of automatic and gene-controlled cell death, cell apoptosis involves complicated regulatory mechanism and stimulates no inflammation, which is essentially different from necrosis. Many researches proved that the apoptosis of pancreatic acinal cells, which might be a protective reaction, had been observed both in experimental and clinical acute pancreatitis, and it had shown an inverse correlation with the severity of diseases. The purpose of this article is to summarize the advances in the mechanism of pancreatic acinar cell apoptosis during acute pancreatitis in recent years, and to expound the therapeutic approaches in the treatment of acute pancreatitis.

关 键 词：急性胰腺炎 腺泡细胞 凋亡 治疗 

分 类 号：R576[医药卫生—消化系统]