热休克蛋白70系列与应激性溃疡之间的相互关系  

Relationship between heat shock protein 70 and stress ulcer

作　　者：王鹤[1] 曲彦[2] 

机构地区：[1]青岛大学医学院护理学院,山东省青岛市266023 [2]青岛大学医学院附属市立医院ICU,山东省青岛市266011

出　　处：《世界华人消化杂志》2007年第10期1121-1125,共5页World Chinese Journal of Digestology

摘　　要：生物细胞在受到各种理化因素刺激后,可以产生一系列的应激反应,诱导热休克蛋白(heat shock protein,HSP)表达．在众多的HSP中, HSP70家族是生物进化过程中最为保守也是目前人们研究最多的一组蛋白．应激可以诱导机体胃黏膜的损伤并可以降低胃黏膜的屏障保护作用,进而导致应激性溃疡的产生,同时加速热休克蛋白的合成,而热休克蛋白反过来又可预防应激性溃疡的发生,抑制胃黏膜细胞凋亡,促进胃溃疡的愈合．本文综述了主要的热休克蛋白分子的分类、调节以及在应激性渍疡中的表达和应用,并简要论述了通过诱导热休克蛋白表达而作为胃黏膜保护剂的几种药物．Biologic cells produce a series of stress reaction after being attacked by various kinds of physical and chemical factors, which induces the expression of heat shock proteins （HSPs）. As the most conservative protein of HSPs, HSP70 family was studied most. Stress can induce gastric mucosal damage and reduce the protective function of mucosal barrier, resulting in the formation of stress ulcer. At the same, stress can accelerate the synthesis of HSP70, but in turn, HSP70 can prevent the occurrence of stress ulcer, inhibit the apoptosis of gastric mucosal cells and promote the healing of gastric ulcer. In this article, we reviewed the regulation and main classification of HSPs, the expression of HSPs and its role in stress ulcer, and several drugs （targeting on the induction of HSP expression） for the protection of gastric mucosa.

关 键 词：热休克蛋白 应激性溃疡 胃黏膜保护 

分 类 号：R573.1[医药卫生—消化系统]