门诊抑郁症患者医药费用及生命质量研究  

The Medical Cost of Depressed Outpatients in Shanghai and 6-month Follow-up Study with Treatment of Paroxetine

作　　者：刘文娟[1] 季建林[1] 吴文源[2] 史以珏[3] 王崇顺[4] 陈兴宝[5] 

机构地区：[1]复旦大学附属中山医院心理医学科,上海200032 [2]同济大学附属同济医院,上海200065 [3]交通大学附属瑞金医院,上海200025 [4]交通大学附属上海第一人民医院,上海200080 [5]复旦大学公共卫生学院,上海200032

出　　处：《中国临床医学》2007年第2期273-275,共3页Chinese Journal of Clinical Medicine

摘　　要：目的:分析门诊抑郁症患者用药情况,研究其因患抑郁症而导致的年经济负担,评价抗抑郁药物(帕罗西汀)的疗效以及对生命质量的影响。方法:多中心合作研究,对652例符合抑郁症诊断标准患者进行用药情况和经济负担相关信息调查。其中180例用帕罗西汀治疗6个月,采用HAMD-17、HAMA和SF-36分别在治疗前、治疗3个月和6个月进行疗效与生命质量评价。结果:(1)抑郁症门诊患者用药SSRIs占主导地位(90．18％);(2)上海市门诊抑郁症患者的年经济负担高达1．33亿元,其中因门诊治疗抑郁症患者而花费的直接医疗费用为0．67亿元;(3)抑郁症门诊患者的生命质量显著下降(QOL<50分),但治疗后QOL评分显著提高(>70分,P=0．00),并且抑郁症状和焦虑症状的缓解率(HAMD或HAMA<8分)分别达70％和88％。结论:抑郁症会对患者、家庭以及社会造成沉重的经济负担,但如果及时给予治疗,帕罗西汀能显著改善抑郁和焦虑症状和提高其生命质量。Objective： It aims to investigate the use of antidepressants and the annual economic burden among depressed outpatients in Shanghai, and to assess the quality of life （QOL） and effectiveness of paroxetine on depression. Methods： It was a multi-center collaborative clinical trial and 652 major depressed cases were inquired for economic burden and drug treatment investigation. There were 180 outpatients treated with paroxetine and assessed with HAMD, HAMA and SF-36 before and after treatment. Results：（1）SSRIs were most common used for treatment of depression in clinical practice now （90.18%）. （2） The total economic burden of depressed outpatients in shanghai was estimated about 133 million RMB a year（values in 2003）, and about a half of them for direct medical costs. 3） The depressed patients had a poor QOL （score less than 50）, but after treatment, they had a great improvement in QOL （scores over 70） and depressive and anxiety symptoms. Conclusion：Depression as a mental disorder can create a huge burden on the patient themselves, their families, and the society. If antidepressant was given as soon as possible, the QOL and associated depressive and anxiety symptoms will be improved obviously among the depressed outpatients.

关 键 词：抑郁症 年经济负担 帕罗西汀 生命质量 缓解 

分 类 号：R749.4[医药卫生—神经病学与精神病学]