致敏大鼠心脏移植后红细胞免疫功能变化  

Changes in erythrocyte lmmunity in donor-skin sensitized rats after heterotoptic heart transplantation

作　　者：陈凡[1,2,3] 宋惠民[1,2,3] 李跃华[1,2,3] 宋静[1,2,3] 徐巨林[1,2,3] 

机构地区：[1]南京铁道医学院附属医院胸心外科 [2]山东医科大学附属医院心外科 [3]山东医科大学免疫室

出　　处：《铁道医学》1997年第1期8-9,共2页Railway Medical Journal

基　　金：山东省科委资助

摘　　要：目的考察红细胞免疫在大鼠皮肤及心脏移植后的变化情况及与其它细胞免疫指标变化的相关关系。方法在心脏移植前，Ａ组先用供体皮肤致敏，Ｂ组再于致敏前作供体抗原经胸腺耐受诱导，Ｃ组单纯作心脏移植，并于心脏移植围手术期动态测定红细胞免疫，在移植排斥高峰心脏停跳时测定迟发型超敏反应（ＤＴＨ）、淋巴细胞转化率变化。结果供体皮肤或心脏移植后，随时间推移，红细胞免疫花环率也上升，在排斥终点时达最高峰，而免疫耐受组升高不明显，其变化与ＤＴＨ及淋转率呈明显正相关关系。结论红细胞免疫能够间接反映皮肤及心脏移植后机体免疫状态，对预测移植后急性排斥有一定意义。Objective The aim of this study is to assess:1.the changes in RBC immunity in donor-skinsensitized rats after heterotopic heart transplantation,2.whether there is any correlation between RBC immunity and cell-mediated immunity.Methods Before heart transplantation,group A was sensitized with donor skin,group B was preconditioned intrathymically with donor antigen to induce tolerance before skin transplantation and group C was heart transplanted alone.RBC immunity was meassured periodically,DTH and lymphocyte transformation rates were measured at the time of heart beat cessation. Results After donor skin or heart transplantation the RBC immunity increased gradually and reached to its climax at the time of heart beat stopping.It had a positive correlationship with those of DTH and lymphocytes transformation rates.The MST of toleranced group was the longest in the groups studied.Its RBC immunity was not elevated evidently. Conclusion The RBC immunity used as a useful surveillance index for acute transplant rejection deserves to be studied thoroghly.

关 键 词：红细胞免疫 心脏移植 排斥反应 

分 类 号：R654.203[医药卫生—外科学]