江苏省恶性肿瘤高发地区胃癌病例对照研究  

Case-control analysis on stomach cancer in a high cancer incidence area of Jiangsu province

作　　者：刘爱民[1] 赵金扣[1] 武鸣[2] 圣龙贵[3] 陈娟[3] 顾小平[3] 杨婕[2] 周金意[2] 张作风 

机构地区：[1]南京医科大学公共卫生学院流行病与统计学系,南京210029 [2]江苏省疾病预防控制中心 [3]江苏省大丰市疾病预防控制中心 [4]美国加州洛杉矶大学公共卫生院

出　　处：《中国公共卫生》2007年第5期575-576,共2页Chinese Journal of Public Health

基　　金：江苏省医学135工程重点人才研究基金(RC2003090)

摘　　要：目的分析江苏省恶性肿瘤高发地区胃癌发病的相关因素。方法选择江苏省恶性肿瘤高发地区大丰市进行以人群为基础的胃癌1：2病例-对照研究,共调查病例646例,对照1292人。采用单因素及多因素非条件Logistic回归方法进行分析。结果喜食烫食（OR=2.2841,95%CI：1.2609～4.1376）、进食速度快（OR=2.9668,95%CI：2.2736～3.8714）、喜食辣食品（OR=2.4875,95%CI：1.3644～4.5352）、癌症家族史（OR=1.4224,95%CI：1.1041～1.8325）等为胃癌发病的主要危险因素,而粮食储具常清洗翻晒（OR=0.5713,95%CI：0.4429～0.7368）、喜食大蒜（OR=0.6299,95%CI：0.4567～0.8687）、使用冰箱（OR=0.6256,95%CI：0.4104～0.9537）、饮茶（OR=0.4541,95%CI：0.3292～0.6263）、性格开朗（OR=0.5157,95%CI：0.3147～0.8453）等则为保护因素。结论应通过教育改变居民不良的生活饮食习惯以及注意心理精神卫生,以降低胃癌的发病危险性。Objective To explore the associated factors with the risk of stomach cancer in a high cancer incidence area of Jiangsu province. Methods A population-based case- control study including 646 cases and 1292 controls was conducted in Dafeng county, one of the high cancer incidence areas in Jiangsu province. Cases consisted of patients with newly diagnosed histologically confirmed gastric cancer. Controls were cases admitted during the study period without diagnostic gastrointestinal diseases . Univariate and multivariate non-conditional Logistic regression analyses were used to identify associated factors of stomach cancer. Results Hot food（ OR = 2.2841,95 % CI ： 1.2609 - 4.1376）, fast eating speeding （ OR = 2.9668, 95 % CI：2.2736-3.8714）,peppery food （OR =2.4875,95% CI： 1.3644-4.5352）, family cancer history（OR = 1.4224, 95% CI ： 1. 1041 - 1. 8325）significantly increased the risk of developing stomach cancer, while often washing grain container（ OR = 0. 5713, 95 % CI ： 0.4429 - 0. 7368）, eating raw garlic （ OR = 0. 6299, 95 % CI ： 0.4567 ～ 0. 8687）, using refrigeratory （ OR = 0. 6256, 95 % CI ： 0.4104 - 0. 9537 ）, tea drinking （OR = 0. 4541, 95 % CI ： 0. 3292 ～ 0. 6263）, optimistic character （ OR = 0.5157, 95% CI：0.3147～0.8453）were protective factors for the stomach cancer. Conclusion Healthy lifestyle and dietary pattern, and healthy psychological status could reduce the risk of stomach cancer in the high cancer incidence area.

关 键 词：胃癌 危险因素 病例-对照研究 非条件LOGISTIC回归分析 

分 类 号：R735.1[医药卫生—肿瘤]