PTEN蛋白和p27在胃癌中的表达和相关性研究  

The research on expression of PTEN protein and p27 in gastric carcinoma

作　　者：巩方明[1] 刘洪俊[1] 

机构地区：[1]山东大学山东省立医院普外科,山东济南250012

出　　处：《中国现代普通外科进展》2007年第2期138-141,共4页Chinese Journal of Current Advances in General Surgery

基　　金：山东省科技厅科技攻关资助项目(2006GG2202025)

摘　　要：目的:研究胃癌中抑癌基因PTEN和p27的表达和两者间的关系。方法:应用免疫组化方法检测36例胃癌组织、10例癌旁组织和8例正常胃组织中PTEN和p27蛋白的表达情况。结果:胃癌组织中PTEN和p27阳性表达率分别为61.1%(22/36)和63.9%(23/36)(P>0.05),均低于正常胃组织阳性率100%(P<0.05)胃癌组织中PTEN和p27阳性表达存在正相关关系(r=0.3043P<0.05),结论:PTEN和p27基因的异常改变参与胃粘膜细胞的恶性转化过程,PTEN和p27蛋白表达水平可作为评价胃癌病理生物学行为的客观指标之一。Objectives： To study the correlation between PTEN and p27 expression in gastric carcinoma. Methods： Immunohistochemistry was applied to examine the expression of P-i-EN and p27 in 36 cases of human gastric carcinoma, 10 cases of tumor-side ward mucosa and 8 cases of normal gastric mucosa. Results： Positive expressive rates of PTEN （61.11% ,22/36） and p27 （63.89%, 23/36） in gastric cancer were lower than those in normal gastric epithelium （100%, 8/ 8）, but without significant differences （P〉0.05）. The expression of PTEN and p27 in gastric cancer correlated with each other （r=0.3043, P〈0.05）. Conclusion： The abnormal expression of tumor suppressor gene PTEN and p27 participate the malignant conversion process of the gastric mucosa cell and the expression levels of the PTEN and p27 protein may be used to evaluate the pathologic biology behavior of gastric carcinoma.

关 键 词：胃肿瘤 第10号染色体同源丢失性磷酸酶-张力蛋白 P27 

分 类 号：R735.2[医药卫生—肿瘤]