山东省某地区精神分裂症患者6号染色体的基因组扫描研究  

A genomic screen for genetic loci associated with schizophrenia on chromosome 6 in certain region of Shandong Province

作　　者：朱海宁[1] 陈刚[1] 温晓燕[1] 林汝湘[1] 朱建平[2] 魏然[1] 周鹏[1] 栾萌[1] 于锡巧[1] 刘文敏[1] 高春义[1] 翁正[3] 

机构地区：[1]山东省医学科学院基础医学研究所现代医用药物与技术重点实验室,济南250062 [2]潍坊市第三人民医院精神科 [3]山东省精神卫生中心防治科

出　　处：《中华精神科杂志》2007年第2期82-85,共4页Chinese Journal of Psychiatry

基　　金：国家自然科学基金(30440042);山东省自然科学基金重点资助项目(Z2004C10)

摘　　要：目的在6号染色体上寻找与精神分裂症的关联区域,进而定位精神分裂症的致病基因。方法在6号染色体采用间隔10 cM(厘摩)遗传距离的20个微卫星遗传标记,分别对山东省潍坊市东部地区119例精神分裂症患者和119名正常对照者的 DNA 混合样本进行基因组扫描,比较两组每个等位基因峰值比率的差异。结果患者组 D6S289和 D6S460两个遗传位点上的等位基因频率分别为0.121和0.200,高于对照组(分别为0.046和0.157,P<0.01),而患者组 D6S1610遗传位点的等位基因频率(0.087)低于对照组(0.161,P<0.01)。结论山东省潍坊市东部地区的精神分裂症患者中存在与6号染色体的关联区域,致病因子(基因或调控因子等)可能位于其中。Objective To find regions on chromosome 6 associated with schizophrenia and genes responsible for the etiology of schizophrenia. Methods A total of 20 microsatellite markers on chromosome 6 spaced at average of 10 cM was selected and two separated DNA pooling samples consisting of 119 schizophrenic cases and 119 normal controls was genotyped respectively, and compared the difference in the ratio of each allele between the two groups. Results The allele frequencies on the D6S289 and D6S460 loci were greater in patients than that in controls （0. 121 vs. 0. 046 and 0. 200 vs. 0. 157 ; all P 〈0. 01 ）, while the allele frequency on D6S1610 locus was greater in controls than that in patients （0. 161 vs. 0. 087; P 〈 0. 01 ）. Conclusion The regions on chromosome 6 may be associated with schizophrenic in this sample, and further screen of candidate genes in these area are needed.

关 键 词：精神分裂症 染色体 人 遗传 基因组 基因池 

分 类 号：R749.3[医药卫生—神经病学与精神病学]