去甲长春花碱联合顺铂治疗蒽环类和紫杉类治疗失败的晚期乳腺癌的疗效  

Navelbine and Cisplatin for the Treatment of Metastatic Breast Cancer Failed to Anthracyclines and Taxanes

作　　者：高宏丽[1] 张兆明[1] 崔海青[1] 闵令娥[1] 

机构地区：[1]山东省济南市第四人民医院内科,250031

出　　处：《中国全科医学》2007年第9期745-746,共2页Chinese General Practice

摘　　要：目的观察去甲长春花碱(NVB)和顺铂(DDP)联合方案治疗蒽环类及紫杉类治疗失败的晚期乳腺癌的疗效和安全性。方法NVB联合DDP治疗蒽环类及紫杉类治疗失败的晚期乳腺癌患者40例。化疗剂量:NVB25mg/m2,第1、8d;DDP80mg/m2,分3d给药(第3～5d)同时水化,21d为1个周期,至少治疗2个周期。结果共完成156个周期,中位数4个周期。完全缓解(CR)4例(10.0%),部分缓解(PR)17例(42.5%),稳定(SD)14例(35.0%),进展(PD)5例(12.5%),总有效率(CR+PR)52.5%,中位肿瘤进展时间(TTP)6.5个月。主要毒副作用为骨髓抑制及胃肠道反应,Ⅲ～Ⅳ度恶心呕吐、白细胞下降及血小板下降的发生率分别为12.5%、32.5%及5.0%。结论NVB联合DDP对蒽环类及紫杉类药物治疗失败的晚期乳腺癌疗效较好,不良反应小,是蒽环类及紫杉类药物治疗失败的晚期乳腺癌的有效解救方案。Objective To investigate the efficacy and safety of the combination chemotherapy with navelbine and cisplatin in the treatment of metastatic breast cancer （MBC） previously failed to anthracyclines and taxanes. Methods 40 patients with MBC failed to anthracyclines and taxanes were treated from Jan. 2004 to Sept. 2005. The navelbine were administered 25 mg/m^2, d 1,8 ;cisplatin 80 mg/m^2,in 3 days （day 3 to 5）. 21 days per cycle and at least 2 cycles per patient. Results A total of 156 cycles were completed and the median was 4. Among the 40 cases, CR, PR, SD, PD were observed in 4 （ 10. 0% ）, 17 （ 42. 5% ）, 14 （35.0%） ,5 （ 12. 5% ） cases respectively. The overall response rate （ CR ＋ PR） was 52.5%, and the median TIP was 6.5 months. The main toxicities were myelo - suppression and vomiting with WHO grade Ⅲ - Ⅳ vomiting, neutropenia and thrombo - cytopenia being in 12.5% （5/40） ,32. 5% （13/40） and 5.0% （2/40）. Conclusion The regi - men of navelbine combined with cisplatin is proved to be an effective, safe,and low- cost chemotherapy regimen in the patients with MBC failed to anthracyclines and taxanes.

关 键 词：去甲长春花碱 顺铂 蒽环类及紫杉类治疗失败 晚期乳腺癌 

分 类 号：R730.52[医药卫生—肿瘤] R737.9[医药卫生—临床医学]