人体角膜内皮细胞的共焦显微镜研究  

The study of the human corneal endothelium by in vivo confocal microscopy

作　　者：黎明[1] 林跃生[2] 姚晓明[1] 陈家祺[2] 陈龙山[2] 宋书华[2] 肖启国[2] 黄挺[2] 周世有[2] 

机构地区：[1]暨南大学附属深圳市眼科医院,深圳510060 [2]中山大学中山眼科中心

出　　处：《中国实用眼科杂志》2007年第5期479-482,共4页Chinese Journal of Practical Ophthalmology

摘　　要：目的应用共焦显微镜观察活体角膜内皮细胞的形态学特征。方法应用共焦显微镜观察正常人（20例）、角膜炎（12例）、角膜移植术后（19例）、葡萄膜炎（5例）、大疱性角膜病变（3例）、角膜白斑（6例）、角膜营养不良（7例）、青光眼（10例）、圆锥角膜（17例）等患者的角膜内皮,分析所得活体角膜内皮图象,总结其形态学特征。结果活体共焦显微镜下角膜内皮的图象主要有8种：①完全正常角膜内皮。②水肿角膜内皮。③失代偿角膜内皮。④“激活”角膜内皮。⑤排斥角膜内皮。⑥有KP角膜内皮。⑦有“疣状物”的角膜内皮。⑧“双核”角膜内皮细胞。结论共焦显微镜能对活体角膜内皮进行实时、无创、准确以及可重复、可比较的观察。Objective To observe and analyze the morphologic characteristics of the human corneal endothelium by in vivo confocal microscope（Confoscan2.0）. Methods To observe and analyze the human corneal endothelium by in vivo confocal microscope, and summarize the morphologic characteristics. The patients were as followed： normal volunteers （20 eyes）, keratitis （12 eyes）, keratoplasty （19 eyes）, uveitis （5 eyes）, bubble keratopathy （3 eyes）, corneal leukoma （6 eyes）, corneal dystrophy （7 eyes）, glaucoma （10 eyes）, keratoconus （17 eyes）. Results There were eight kinds of the human corneal endothelial images mainly by in vivo confocal microscope, including： ① the normal corneal endothelium of in vivo confocal microscope. ② the edema endothelium. ③ the uncompensable endothelium. ④ the activated endothelium. ⑤ the rejection endothelium. ⑥ the endothelium with KP. ⑦ the verrucous endothelium. ⑧ the doeble-nuclei endothelium. Conclusion The endothelial value of in vivo confocal microscope was accurate, sensitive, real time, no wounding, in vivo and repeatable, comparatable.

关 键 词：共焦显微镜 角膜 内皮细胞 人类 

分 类 号：R772.2[医药卫生—眼科]