周围型肺癌CT征象及预后与Cyclin D1表达的相关性研究  

Relationship between Cyclin D1 expression and CT sign and prognosis in peripheral lung cancer

作　　者：马树华[1,2] 徐克[3] 肖壮伟[1,2] 孙政育[4] 刘源[1] 林顺发[1] 邓世华[1] 李玉光[1] 

机构地区：[1]汕头大学医学院第一附属医院放射科 [2]汕头大学医学院广东省医学分子影像重点实验室,广东汕头515041 [3]中国医科大学第一附属医院放射科 [4]哈尔滨市第一医院放射科

出　　处：《中华肿瘤防治杂志》2007年第7期529-533,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：汕头市科技局[汕府科(2006)85号];哈尔滨市科技局(2003AFXQJ05239)资助

摘　　要：目的探讨周围型肺癌CT征象及预后与Cyclin D1表达的关系。方法利用免疫组化SP法及螺旋CT扫描,回顾分析92例经病理确诊的周围型肺癌Cyclin D1基因表达与CT征象及其预后的关系。结果深分叶、棘突征、短细毛刺征、纵隔淋巴结转移与Cyclin D1表达有关,χ2值分别为6.139、4.727、4.756和5.220,P值均<0.05;肿瘤大小、空洞、胸膜凹陷、组织类型、肿瘤分化程度、肿瘤TNM分期、年龄、性别与Cyclin D1表达无关,χ2值分别为0.244、0.004、0.411、1.523、0.391、0.040、1.104、1.896,P值均>0.05。Cyclin D1过度表达与预后有关。Cyclin D1为一负性预后因子,其过度表达提示预后不良。结论Cyclin D1表达在肺癌的发生、发展及CT征象中可能起重要作用,检测该基因并结合CT征象可作为临床诊断及预后评估的指标。OBJECTIVE： To investigate Cyclin D1 expression in peripheral lung cancer and its relationship with the CT sign and prognosis. METHODS： Cyclin D1 expression in peripheral lung cancer and its relationship with the CT sign and prognosis were analyzed retrospectively by means of SP immunohistochemical technique and spiral CT scanning in ninety-two patients with peripheral lung cancer proved by pathology. RESULTS： Cyclin D1 expression was related to deep lobulation, spiculate protuberance, short thin spinule sign and mediastina lymph node metastasis, X^2 values were 6. 139, 4. 727, 4. 756, 5. 220 respectively, all P values〈0.05, rather than tumor size, cavity, pleural indentation, histological type, differentiation, tumor TNM stage, age and sex, 2 values were 0.244, 0.004, 0.411, 1. 523, 0.391, 0.040, 1. 104, 1. 896 respectively, all P values 0.05. Cyclin D1 was a negative prognostic factor whose overexpression indicated a worse prognosis. CONCLUSIONS： Cyclin D1 expression may play an important role in the occurrence, progress and CT sign of lung cancer. Cyclin D1 is a negative factor whose overexpression implies a worse prognosis. Detection of the gene and observation of the CT sign can be considered as indexes of clinical diagnosis and prognostic evaluation.

关 键 词：肺肿瘤/病因学 肺肿瘤/放射摄影术 细胞周期蛋白D1/生物合成 

分 类 号：R734.2[医药卫生—肿瘤]