2型糖尿病合并非酒精性脂肪肝的危险因素分析  

Analysis of risk factors on nonalcoholic fatty liver disease in patients with type 2 diabetes

作　　者：赖丽萍[1] 陆泽元[1] 邵豪[1] 庄荀芳[1] 邹钢[1] 柳岚[1] 庄雄杰[1] 

机构地区：[1]广东医学院附属福田人民医院内分泌科,广东省深圳市518033

出　　处：《中国综合临床》2007年第6期497-499,共3页Clinical Medicine of China

摘　　要：目的探讨影响2型糖尿病合并非酒精性脂肪肝（简称脂肪肝）的主要危险因素。方法2型糖尿病伴有脂肪肝（DFL）组109例,2型糖尿病不伴脂肪肝（NDFL）组90例,采用空腹C肽代替胰岛素改良HOMA公式评价胰岛素抵抗。结果DFL组体质指数、腰围、腰臀比、甘油三酯、血尿酸和HOMA-IR（CP）升高（均P〈0.01）;Logistic回归分析表明体质指数、高甘油三酯血症、高尿酸血症和胰岛素抵抗是DFL形成的独立危险因素。结论DFL的独立危险因素是肥胖、高甘油三酯血症、高尿酸血症和胰岛素抵抗;脂肪肝是代谢综合征的一个组成部分。Objective To investigate risk factors of nonalcoholic fatty liver disease （ called ＂fatty liver＂ for short） in patients with type 2 diabetes, Methods The investigation was conducted by means of case control study, including 109 patients of type 2 diabetes with fatty liver （DFL） ,90 type 2 diabetes without fatty liver （NDFL）, Fasting C-peptide to replace insulin in homeostasis model assessment （HOMA） was applied to assess the status of insulin resistance, Results Patients with fatty liver in type 2 diabetes had markedly higher body mass index （BMI） , waist circumference （ WC ）, waist- to hip ratio, triglyceride, hyperuricermia and HOMA-IR （CP） than those in controls （P 〈 0.01 for all）. Logistic regression analysis showed that BMI, hyperglycemia , hyperuricermia and insulin resistance were the main risk factors for forming fatty liver, Conclusion The independent risk factors for forming fatty liver are obesity , hyperglycemia, hyperuricermia and insulin resistance in type 2 diabetes, DFL was probably one of components of metabolic syndrome.

关 键 词：脂肪肝 2型糖尿病 胰岛素抵抗 危险因素 

分 类 号：R575[医药卫生—消化系统] R587[医药卫生—内科学]