酸浆化学成分及酸浆苦素G的结构订正  

Chemical Constituents from Physalis alkekengi and Structural Revision of Physalin G

作　　者：陈荣[1] 梁敬钰[1] 杨洋[1] 刘睿[1] 

机构地区：[1]中国药科大学天然药物化学教研室,南京210009

出　　处：《中国天然药物》2007年第3期186-189,共4页

摘　　要：目的：对吉林产酸浆的化学成分进行研究。方法：运用层析手段和波谱方法分离并鉴定了8个化合物。结果：对酸浆苦素G（physalin G，1）的结构进行了订正并对其核磁数据进行了正确归属，其余化合物分别为酸浆苦素A（physalin A，2），酸浆苦素B（physalin B，3），酸浆苦素D（physalin D，4），酸浆苦素P（physalin P，5），金圣草黄素（chrysoeriol，6），马尾藻甾醇（saringosteml，7），丁香酸（syringicacid，8）。结论：化合物1的6位构型订正为尺，化合物6～8为首次从该属中分离得到。AIM： To study the chemical constituents of Physalis alkekengi L. var. franchetii （Mast.） Makino. METHODS： Many kinds of chromatographic methods were used in the isolation procedure, while the structures of isolated compounds were elucidated on the basis of spectral and physico-chemical analysis. RESULTS： Eight compounds were isolated and structurally identified. The structure of physalin G（1） was revised, and its NMR signals were assigned by 2D-NMR for the first time. The other compounds were identified as physalin A （ 2 ）, physalin B （ 3 ）, physalin D （ 4 ）, physalin P （ 5 ）, chrysoeriol （ 6 ）, saringosterol （ 7 ） and syringic acid （ 8 ）. CONCLUSION： The configuration of 6- C of compound 1 has been revised as R. Compounds 6 ～ 8 have been obtained from this genus for the first time.

关 键 词：酸浆 酸浆苦素 酸浆苦素G 

分 类 号：R284.1[医药卫生—中药学]