同型半胱氨酸与高原地区急性脑梗死关系的探讨  

Changes in plasma homocysteine in acute cerebral infarction at high altitude

作　　者：楮以德[1] 朱爱琴[1] 李英兰[1] 吴世政[2] 娄明元[1] 张俊霞[2] 于梅花[3] 杨晓丽[1] 

机构地区：[1]青海省人民医院老年病研究所,青海西宁810007 [2]青海省人民医院神经内科,青海西宁810007 [3]青海省人民医院放射免疫检验科,青海西宁810007

出　　处：《中风与神经疾病杂志》2007年第2期206-208,共3页Journal of Apoplexy and Nervous Diseases

基　　金：国家人事部留学人员科技活动项目[编号:青人专字(2006)2号]

摘　　要：目的探讨不同高海拔地区急性脑梗死(acute cerebral infarction,ACI)与血浆同型半胱氨酸(Homocysteine,Hcy)水平的关系。方法采用发光免疫法测定高海拔地区ACI患者40例,中度海拔地区ACI患者48例及70例不同海拔健康对照组血浆Hcy、叶酸(FA)和维生素B12(VitB12)浓度。结果不同海拔地区ACI组患者血浆Hcy水平明显升高,FA水平明显低于各对照组(P<0.01)。与中度海拔ACI组相比,高海拔ACI组Hcy水平显著增高,FA的含量显著降低。健康对照组随着海拔增高Hcy的含量增高而FA的含量降低。VitB12在4组间变化不大。ACI组Hcy与FA间呈负相关(r=-0.034,P<0.05)。与VitB12相关不显著。结论高Hcy血症与高原地区急性脑梗死有密切关系。Objective To study the relationship between the homocysteine（Hcy） level and acute cerebral in- farction（ACI） at various high altitude. Methods Four groups from the Qinghai-Tibetau Plateau were collected：40 patients of ACI at 3,400m above sea levels,48 patients of ACI at 2,280m sea levels, 70 controls with various high altitudes. Plasma Hcy,Vitamin B12（VitB12） and folic acid （FA） were assayed by the fluorescence polarization immunoassay （FPTA）. Results （1） Plasma Hcy of patients with ACI was higher and plasma FA of patients with ACI was lower than each control groups at various ahitudes（P〈0. 01）. （2） The levels of Hcy increased remark- ably in patients with ACI of high altitude as compared with that of middle altitude. FA decreased significantly in patients with ACI as compared with that of middle altitude. （3） In control groups ,Hcy exhibited an increase and FA was also significantly decreased with altitudes. VitB12remained no significant difference in four groups. （4） Hcy was significantly negatively correlated with FA （r=0. 034,P〈0. 05）. Conclusion There is a close relationship between hyperhomocysteine and acute cerebral infarction at high altitude.

关 键 词：急性脑梗死 同型半胱氨酸 叶酸 维生素B12 高海拔 

分 类 号：R743.33[医药卫生—神经病学与精神病学]