当归超微粉的药剂学研究  

Pharmaceutical Characteristics of Angelica Sinensis Micropowder

作　　者：孙强[1] 何应[1] 

机构地区：[1]天津大学药物科学与技术学院,天津市300072

出　　处：《中国药房》2007年第15期1141-1143,共3页China Pharmacy

摘　　要：目的:比较当归超微粉和普通粉的粉体学特征及溶出特点,探索超微粉碎技术在中药当归中的应用。方法:通过重压式超微粉碎机制备当归超微粉末;通过扫描电子显微镜(SEM)观察超微粉和普通粉的形貌和细胞特征,用激光粒度分析仪对2种粉末进行粒径分布测定,并对粉体学参数休止角和堆密度进行测定;采用高效液相色谱法测定阿魏酸的含量;用恒温搅拌溶出法对2种粉末主要成分溶出特点的关系进行研究。结果:当归超微粉和普通粉的粉体学特征、表面形态、溶出成分含量差异显著;通常情况下当归超微粉相应成分溶出的速度与浓度要高于普通粉。结论:微粉化能促进当归有效成分的充分利用,超微粉碎技术应用于当归具有可行性和必要性。OBJECTIVE： To compare the powder characteristics and dissolution rate between common powder and micropowder of Angelica sinensis and to explore the application of micronization technology to Angelica sinensis （a traditional Chinese medicine）. METHODS： The micropowder of Angelica sinensis was prepared by heavy pressure micronizer; the shapes and cellular characteristics of the two sorts of powders of Angelica sinensis were surveyed with scanning electron microscope. The particle size distribution was determined by laser diffraction analyzer. The angle of repose and the bulk density were measured. The content of Ferulic acid was determined by HPLC and the correlation of the dissolution rate of the active ingredients in the two powders was studied by constant temperature mixing dissolution method. RESULTS： There were significant differences between common powder and micropowder in particle characteristics, surface morphology and dissolution rate. Usually, the dissolution rates and the concentrations of the corresponding ingredients in micropowder were higher than the common powder of Angelica sinensis. CONCLUSION： Micronization is helpful for the utilization of the active components in Angelica sinensis, and the application of micronization technology to Angelica sinensis is feasible and necessary.

关 键 词：当归 超微粉碎 扫描电子显微镜 溶出速度 

分 类 号：R94[医药卫生—药剂学] R28[医药卫生—药学]