河南林州食管癌高发区反流性食管炎调查  

Investigation on Reflux Esophagitis Inhabitant Health Status from the Subjects at High Incidence Area in Linzhou,Henan Province

作　　者：李苹娟[1] 王立东[1] 刘保池[1] 杨孟选[1] 申秋[1] 裴辉[1] 胡维信[1] 李琮宇[1] 吴会芳[1] 张梅[1] 

机构地区：[1]河南省食管癌重点开放实验室,郑州大学基础医学院,河南郑州450052

出　　处：《肿瘤基础与临床》2007年第3期185-186,共2页journal of basic and clinical oncology

基　　金：国家自然科学基金(编号:30025016);河南省医学创新人才工程项目(编号:200084)

摘　　要：目的探讨河南食管癌高发区林州居民反流性食管炎(reflux esophagitis,RE)的流行特征,加深对食管癌变机理的了解。方法采用统一RE问卷对河南省食管癌高发区508人进行逐一问卷调查。根据反流性食管炎的症状评分,≥12分为阳性诊断标准。结果RE评分≥12分者28人(6%):女性RE检出率(4%,20/508)明显高于男性(2%,8/508)(P<0.05)。结论女性RE发生率明显高于男性,与食管癌男性明显高于女性的性别分布相反,也明显低于西方国家RE发生率,提示可能RE与食管腺癌关系较与食管鳞癌关系密切。Objective To determine the prevalence of reflux esophagitis （RE） from the subjects in the high incidence area for esophageal cancer in Linzhou, Henan province and to further understanding the mechanism of esophageal carcinogenesis. Methods 508 subjects in high risk area for esophageal cancer were intervened with RE questionnaire. RE diagnosis was made on the subjects with ≥ 12 score based on the RE symptom scoring. Results 28 subjects were observed with 〉112 score for RE symptom（6% ）. The detection rate for the female（4% , 20/508） was apparently higher than in male（2% , 8/508 ） （ P 〈 0.05 ）. Conclusions The prevalence of RE in females is higher than in males, which is contrast with the prevalence of esophageal cancer（ higher in males than in females）, and is lower than in western country, suggesting that RE may be correlated well with esophageal adenocarcinoma rather than in esophageal squalors cell carcinoma.

关 键 词：反流性食管炎 食管癌 流行病学调查 高发区 

分 类 号：R735.1[医药卫生—肿瘤]