肿瘤干细胞标志物CD133和内皮素转化酶对非小细胞肺癌预后的影响  

Association of CD133 and endothelin-converting enzyme expressions with prognosis of non-small cell lung carcinoma

作　　者：张惠忠[1] 魏益平[1] 王梅[1] 吴澄[1] 杨艳旗[1] 陈炬[1] 曹永科[1] 

机构地区：[1]中山大学附属第二医院心胸外科,广东广州510120

出　　处：《南方医科大学学报》2007年第5期696-699,共4页Journal of Southern Medical University

基　　金：广州市科技攻关引导项目(02Z3-E0016)~~

摘　　要：目的研究肿瘤干细胞标志物CD133和内皮素转化酶(ECE)在非小细胞肺癌(NSCLC)组织中表达的临床意义。方法用免疫组织化学方法检测77例NSCLC组织中CD133和ECE的表达,分析其与肿瘤大小、组织学类型、组织分化程度、淋巴结转移和预后的关系。结果77例NSCLC组织中CD133与ECE的阳性表达率分别为51.9%(40/77)和45.5%(35/77)。CD133和ECE的表达与淋巴结转移呈正相关(r=0.246,P<0.05;r=0.339,P<0.05);CD133和ECE的表达均与患者术后生存时间呈负相关(P<0.05)。CD133和ECE的表达与肿瘤大小、组织学类型和组织分化程度均无关(P>0.05)。CD133与ECE的表达之间呈正相关(r=0.249,P<0.05)。结论肿瘤干细胞标志物CD133和ECE的表达与NSCLC的淋巴转移和预后密切相关,它们的高表达提示患者预后不良。Objective To investigate the expression of tumor stem cell marker CD133 and endothelin-converting enzymes （ECE） in non-small cell lung carcinoma （NSCLC） and their association with NSCLC lymphoid metastasis. Methods CD133 and ECE expressions was detected immunohistochemically in the specimens from 77 patients with NSCLC, and the association of CD133 and ECE expressions with the tumor size, histological type, differentiation, lymphoid metastasis, and prognosis of NSCLC was analyzed. Results The positive expression rate of CD133 and ECE was 51,9% （40/77） and 45.5% （35/77） in these specimens, respectively. Both CD133 and ECE expressions were associated positively with lymphoid metastasis （r=0.246 and 0.339, P〈0.05）, and inversely with the survival time of the patients （P〈0.05）. CD133 and ECE expressions were not related to tumor size, histological type, and differentiation of the tumor （P〉0.05）. CD133 expression was associated positively with ECE expression in NSCLC （r=0.249, P〈0.05）. Conclusion CD133 and ECE expressions are associated with lymphoid metastasis and prognosis of NSCLC, and their overexpression often suggests unfavorable prognosis of NSCLC.

关 键 词：肺肿瘤 CD133 内皮素转化酶 淋巴转移 预后 

分 类 号：R734.2[医药卫生—肿瘤]