CT灌注成像与猴局部脑缺血模型的相关研究  

CT perfusion study of acute local cerebral infarction in rhesus monkeys

作　　者：何卓凯[1] 许乙凯[1] 邱维加[2] 邓燕贤[2] 周志鹏[2] 黄志宏[3] 冯飞铃[4] 韦瑛[4] 甘瑞静[4] 庾俊雄[5] 

机构地区：[1]南方医科大学南方医院影像中心,广东广州510515 [2]桂林医学院附属医院放射科,广西桂林541001 [3]哈佛大学医学院麻省总医院 [4]桂林医学院病理生理学教研室,广西桂林541001 [5]桂林医学院附属医院麻醉科,广西桂林541001

出　　处：《南方医科大学学报》2007年第5期720-724,共5页Journal of Southern Medical University

摘　　要：目的利用猴局部脑缺血模型探讨CT灌注成像在超急性缺血性脑梗塞研究中的意义。方法采恒河猴静脉血制作自体白色血栓,经DSA手术导入至一侧大脑中动脉M1段分支,分别于栓塞前后不同时间段行CT平扫及CT灌注检查,并结合其DSA栓塞结果、临床表现及大脑病理标本综合分析。结果经DSA栓塞并造影证实猴脑一侧大脑中动脉M1分支栓塞成功;于不同时间段行CT灌注扫描,可见相应区域灌注异常,表现为脑血容量及脑血流量降低,造影剂平均通过时间延长;24h后CT平扫亦可见局部低密度梗死灶。结合尸检病理标本,3种检查结果具一致性。结论CT灌注成像能准确判断猴局部脑缺血模型超急性期脑缺血病灶的形成,对临床超急性期脑缺血的早期诊断提供了一种准确、经济及简便的检查方法,特别对指导临床溶栓治疗具有实际应用价值。Objective To explore the value of CT perfusion in early diagnosis and management of superacute local cerebral infarction in rhesus monkeys. Method Acute local cerebral infarction was induced in the rhesus monkeys during digital subtraction angiography （DSA） by introduction of pale thrombus prepared from autologous blood into the M1 branch of the middle cerebral artery （MCA）. Plain CT scan and CT perfusiun scanning were performed at different time points before and after DSA operation, and the results were analyzed in conjunction with the pathologic changes. Results Ischemic lesions were displayed on CT perfusion images, which showed local hypoperfusion, reduced cerebral blood flow and volume, and mean transit time delay in the compromised area. Local hypointense infarct area was identified in plain CT scan 24 h aRer the DSA operation, and the results were in good agreement with pathological examination during autopsy. Conclusion CT perfusion imaging of the brain can accurately capture the cerebral perfusion deficits in acute ischemic stroke before morphologic changes take place, and therefore provides good means for thrombolytic treatment evaluation of stroke.

关 键 词：CT灌注成像 猴 脑缺血 疾病模型 动物 血管造影术.数字减影 

分 类 号：R743.3[医药卫生—神经病学与精神病学]